Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extract

Neto, João Nogueira; Coelho, Tarcísio Mota; Aguiar, Guilherme Carneiro; Carvalho, Laura Rosa; Araújo, Ana Gisélia Portela de; Girão, Manuel João Batista Castelo; Schor, Eduardo

doi:10.1016/j.ejogrb.2010.10.002

Cited by 28 publications

(17 citation statements)

References 22 publications

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“…An Experimental study using this extract showed significant reduction of endometrial focus 9 . Once established that the cat's claw reduces endometriosis experimentally, it is necessary to evaluate the Uncaria tomentosa action mechanism for the treatment of this pathology.…”

Section: Discussionmentioning

confidence: 99%

“…They were organized into three groups, experimental, positive and negative controls. The experimental group (Uncaria group) made use 32mg/day of Uncaria tomentosa extract and the negative control group (Placebo group) used daily 1ml of saline 0.9% based on Neto et al 9 , which showed significant reduction of endometriosis with no clinical complications apparent. The positive control group (leuprolide group) received leuprolide acetate 1mg/kg of body weight applied single subcutaneous dose, based on Oktem et al…”

Section: Discussionmentioning

confidence: 99%

“…The groups were divided as follows: group Uncaria received gavage with 32 mg/ml Uncaria tomentosa extract (Cat's Claw 100mg, Herbarium of Brazil), administered 1ml per day, and the placebo group received daily gavage with 1ml of saline 0.9%, both for 14 days according Nogueira Neto et al 9 . The group leuprolide received leuprolide acetate 1mg/kg of body weight (Lupron TM 3,75mg, ABBOTT of Brazil) single subcutaneous dose 11 .…”

Section: Methodsmentioning

confidence: 99%

“…The processing was done by grinding 160 tablets of 100mg of cat's claw extract (Cat's Claw 100 mg, Herbarium of Brazil) in a porcelain mortar with a pestle, and then proceeding with the dissolution of it in 500 ml 0.9% NaCl in a beaker to mix until smooth. The mixture was made in an average time of 15 minutes, and the total volume was 500ml in suspension with a 32mg/ml concentration 9 . After the end of treatment, a new surgery was done and, at this time, the inventory of the peritoneal cavity was made again.…”

Section: Methodsmentioning

confidence: 99%

“…The induction of endometriosis was performed according to the methodology proposed by Nogueira Neto et al 9 . After 21 days since the first surgery, the rats underwent further surgery again, at which time was made the inventory of the peritoneal cavity with identification and measurement of the autotransplantation focus with a digital pachymeter, followed by calculating the volume using the Degree Classification System of Growth Implants in accordance with Quereda et al 10 [4 (length / 2) x (width / 2) x (height / 2) / 3].…”

Section: Methodsmentioning

confidence: 99%

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Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis

et al. 2011

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PURPOSE: Evaluate the histological changes in parenchyma´s epithelial layer of the uterus and ovarian of rats with induced endometriosis, treated with Uncaria tomentosa extract. METHODS: 29 rats with experimental endometriosis, were selected and divided in three groups: The uncaria group received 32mg/ml of Uncaria tomentosa extract, 1ml administered daily and the placebo group received 1ml of saline 0.9% per day, during for 14 days (both groups); the leuprolide group received leuprolide acetate 1mg/kg body weight applied single subcutaneous dose. In the 15th day of treatment the uterine horn and ovaries were removed for histopathological analysis. RESULTS: The uncaria group presented nine samples (90%) with immature ovarian follicles, whereas the placebo group did not present any case and in the leuprolide group there were eight rats (88%) with the same change. The placebo group showed mature corpus luteum in all animals, occurring less frequent in uncaria (10%) and leuprolide (22%) groups. The uterine epithelium showed weak proliferative in nine (90%) samples of the uncaria group, in two (20%) animals in the placebo group and seven (77.8%) rats in the leuprolide group. CONCLUSIONS: The findings suggest that Uncaria tomentosa has contraceptive effect.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis

et al. 2011

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Medicinal plants and natural compounds in the treatment of experimental endometriosis: A systematic review protocol

Kiani

Lamardi

Laschke

et al. 2016

Evid Based Preclin Med

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Endometriosis is defined as the endometrial tissue growth (containing both glandular and stromal components) on the extra uterine places especially peritoneal and visceral surfaces of the pelvis. The current medical treatments are mainly based on inhibiting oestrogen or treating the symptoms rather than curing the disease. The recurrence rate is nearly high after both current medical and surgical treatments for endometriosis. In recent years, medicinal herbs and other botanical products have become popular for relieving the symptoms of several gynaecologic disorders such as endometriosis. The objective of this systematic review and meta‐analysis is to provide the pre‐clinical researches on medicinal plants (Not Chinese combinations) and its compounds studied in the treatment of experimental endometriosis. It will also prepare the strengths and limitations of available studies and offer future perspectives in this field. The following electronic databases will be searched up to December 2015: Medline (PubMed platform), Scopus. The grey literatures, Google scholar, and the reference list of all known primary articles, and relevant conference proceedings will also be checked. Only non‐Chinese language papers will be placed in our searches or study selection. For assessing the risk of bias of the included studies, we will use the SYstematic Review Centre for Laboratory animal Experimentation risk of bias tool for animal studies (SYRCLE’s RoB tool). If the studies are sufficiently comparable, outcome data will be pooled. For outcome measures where a meta‐analysis is not possible a qualitative data synthesis of the results from individual studies will be performed.

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Oral and Systemic Photoprotection

González

Gilaberte

Juarranz

2016

Principles and Practice of Photoprotection

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Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extract

Cited by 28 publications

References 22 publications

Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis

Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis

Medicinal plants and natural compounds in the treatment of experimental endometriosis: A systematic review protocol

Oral and Systemic Photoprotection

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