Experimental embryology as applied to the upper limb

Tickle, C.

doi:10.1016/0266-7681(87)90177-x

Cited by 13 publications

(4 citation statements)

References 33 publications

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“…Unique features of individual digits are known to develop in utero in response to the zone of polarizing activity, a specialized area of the posterior apical epidermal ridge 41 . In the vertebrate limb bud, signals from the zone of polarizing activity are known to control the pattern of cellular differentiation in a radioulnar direction [41][42][43] . The zone of polarizing activity, through mechanisms currently under investigation, has some regulatory power over the apical epidermal ridge 41 .…”

Section: Discussionmentioning

confidence: 99%

The Association of Radial Deficiency with Thumb Hypoplasia

James

Green

McCarroll

et al. 2004

The Journal of Bone & Joint Surgery

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Section: Discussionmentioning

confidence: 99%

The Association of Radial Deficiency with Thumb Hypoplasia

James

Green

McCarroll

et al. 2004

The Journal of Bone & Joint Surgery

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“…Thumb hypoplasia occurs when the structures on the radial side of the forearm fail to develop normally. The underlying cause of these anomalies is unknown, although signals from the zone of polarizing activity in the vertebrate limb bud are known to control the pattern of cellular differentiation in a radioulnar direction . Blauth classification system has been used to outline hypoplastic thumbs into five degrees which depict increasing severity of deficiency.…”

Section: Discussionmentioning

confidence: 99%

Study of three non‐syndromic cases of congenital thumb aplasia in captive rhesus monkeys

Goldschmidt

Meireles

Calado

et al. 2015

J of Medical Primatology

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Although congenital thumb absence has been reported frequently in humans, their occurrence in macaques is rare. We observed three cases of spontaneous thumb defects in captive female rhesus monkeys. One animal exhibited bilateral absence and two other presented unilateral thumb absence, all with metacarpal integrity. This report presents the clinical, radiological, and genealogical details as well as possible etiologies in an attempt to draw a parallel with humans and other primate species.

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“…It is considered that the AER may control proximo-distal sequence of the development of the limb. The radio-ulna sequence may be controlled by a zone of polarizing avtivity (ZPA) (Wolpert, 1976;Tickle, 1987). The cell might build up the hand and digits according to the information from these regions.…”

Section: Teratogenic Mechansim Of Cleft Handmentioning

confidence: 99%

Clinical and Experimental Studies on Teratogenic Mechanisms of Congenital Absence of Digits in Longitudinal Deficiencies*

Ogino¹,

Kato²

1993

Congenital Anomalies

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In order to clarify teratogenic mechanisms of congenital absence of the digits in longitudinal deficiencies, ulnar deficiency, radial deficiency, central polydactyly, osseous syndactyly and cleft hand (central deficiency) were analyzed. Then, the same anomalies induced in rat fetuses with myleran were analyzed. In ulnar and radial deficiencies, the more severe was the degree of finger deficit, the more severe was the arrest of the forearm bone. The critical periods of these anomalies were earlier than those of other anomalies. Ulnar deficiencies were induced only in Gun: Wistar rats and radial deficiencies only in WKAH/Hkm rats. A genetic factor may influence the teratogenesis of ulnar and radial deficiencies. From histological analysis of tibial deficiency, it may be suggested that the cause of absence of digits in longitudinal deficiency is closely related to a deficit of mesenchymal cells. The analysis of skeletal changes of central polydactylies, osseous syndactylies and cleft hands suggested that there seemed to be the cleft hand formation process from osseous syndactylies and central polydactylies. These anomalies were often observed in both hands in various combinations. They could be induced by the same treatment at the same developmental stage in rats. The teratogenic mechanism of cleft hand seemed to be failure of induction of digital rays in the hand plate.

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Experimental embryology as applied to the upper limb

Cited by 13 publications

References 33 publications

The Association of Radial Deficiency with Thumb Hypoplasia

The Association of Radial Deficiency with Thumb Hypoplasia

Study of three non‐syndromic cases of congenital thumb aplasia in captive rhesus monkeys

Clinical and Experimental Studies on Teratogenic Mechanisms of Congenital Absence of Digits in Longitudinal Deficiencies*

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