Experimental determination of sarcomere force–length relationship in type-I human skeletal muscle fibers

Gollapudi, Sampath K.; Lin, David C.

doi:10.1016/j.jbiomech.2009.06.013

Cited by 67 publications

(69 citation statements)

References 37 publications

(59 reference statements)

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“…We simulated the Table 1 Muscle properties of the model. L OPT , L SL and A are the optimal muscle length, the tendon slack length, and the physiological cross section area (Gollapudi and Lin, 2009;Hill, 1938;Langenderfer et al, 2004;Zajac, 1989 deficiency of the SC by reducing its PCSA to 50% of the normal value. We evaluated the muscle forces, the joint force, the humeral translation, and the glenohumeral contact pattern.…”

Section: Methodsmentioning

confidence: 99%

Importance of the subscapularis muscle after total shoulder arthroplasty

Terrier

Larrea

Camine

et al. 2013

Clinical Biomechanics

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Background: The rotator cuff muscles are the main stabilizer of the glenohumeral joint. After total shoulder arthroplasty using anterior approaches, a dysfunction of the subscapularis muscle has been reported. In the present paper we tested the hypothesis that a deficient subscapularis following total shoulder arthroplasty can induce joint instability. Methods: To test this hypothesis we have developed an EMG-driven musculoskeletal model of the glenohumeral joint. The model was based on an algorithm that minimizes the difference between measured and predicted muscular activities, while satisfying the mechanical equilibrium of the glenohumeral joint. A movement of abduction in the scapular plane was simulated. We compared a normal and deficient subscapularis. Muscle forces, joint force, contact pattern and humeral head translation were evaluated. Findings: To satisfy the mechanical equilibrium, a deficient subscapularis induced a decrease of the force of the infraspinatus muscle. This force decrease was balanced by an increase of the supraspinatus and middle deltoid. As a consequence, the deficient subscapularis induced an upward migration of the humeral head, an eccentric contact pattern and higher stress within the cement. Interpretation: These results confirm the importance of the suscapularis for the long-term stability of total shoulder arthroplasty.

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Section: Methodsmentioning

confidence: 99%

Importance of the subscapularis muscle after total shoulder arthroplasty

Terrier

Larrea

Camine

et al. 2013

Clinical Biomechanics

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“…Finally, a passive fascicle F-L relationship was created by fitting the F-L data using an exponential equation (Gollapudi and Lin, 2009):…”

Section: Subject-specific Passive and Active Force-length Experimentsmentioning

confidence: 99%

On the ascent: the soleus operating length is conserved to the ascending limb of the force-length curve across gait mechanics in humans

Rubenson

Pires

Loi

et al. 2012

Journal of Experimental Biology

102

110

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SUMMARYThe region over which skeletal muscles operate on their force-length (F-L) relationship is fundamental to the mechanics, control and economy of movement. Yet surprisingly little experimental data exist on normalized length operating ranges of muscle during human gait, or how they are modulated when mechanical demands (such as force output) change. Here we explored the soleus muscle (SOL) operating lengths experimentally in a group of healthy young adults by combining subject-specific F-L relationships with in vivo muscle imaging during gait. We tested whether modulation of operating lengths occurred between walking and running, two gaits that require different levels of force production and different muscle-tendon mechanics, and examined the relationship between optimal fascicle lengths (L 0 ) and normalized operating lengths during these gaits. We found that the mean active muscle lengths reside predominantly on the ascending limbs of the F-L relationship in both gaits (walk, 0.70-0.94 L 0 ; run, 0.65-0.99 L 0 ). Furthermore, the mean normalized muscle length at the time of the peak activation of the muscle was the same between the two gaits (0.88 L 0 ). The active operating lengths were conserved, despite a fundamentally different fascicle strain pattern between walking (stretch-shorten cycle) and running (near continuous shortening). Taken together, these findings indicate that the SOL operating length is highly conserved, despite gait-dependent differences in muscle-tendon dynamics, and appear to be preferentially selected for stable force production compared with optimal force output (although length-dependent force capacity is high when maximal forces are expected to occur). Individuals with shorter L 0 undergo smaller absolute muscle excursions (P<0.05) so that the normalized length changes during walking and running remain independent of L 0 . The correlation between L 0 and absolute length change was not explained on the basis of muscle moment arms or joint excursion, suggesting that regulation of muscle strain may occur via tendon stretch.

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“…Despite reasonably good fitting of the scaled sarcomere F-L relation with experimental data of fibres and muscles (see, e.g. Gollapudi and Lin 2009;Winters et al 2011), given complexity of sarcomere mechanics in striated muscles (Pollack 1983;Rassier 2017), precise association of the sarcomere F-L relation with that of muscles requires rigourous theoretical studies.…”

Section: Introductionmentioning

confidence: 99%

Force–length relation of skeletal muscles: from sarcomeres to myofibril

Hou

2018

Biomech Model Mechanobiol

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Sarcomeres are building blocks of skeletal muscles. Given force-length relations of sarcomeres serially connected in a myofibril, the myofibril force-length relation can be uniquely determined. Necessary and sufficient conditions are derived for capability of fully lengthening or completely shortening a myofibril under isometric, eccentric or concentric contraction, and for the myofibril force-length relation to be a continuous single-valued function. Intriguing phenomena such as sarcomere force-length hysteresis and myofibril regularity are investigated and their important roles in determining myofibril forcelength relations are explored. The theoretical analysis leads to experimentally verifiable predictions on myofibril force-length relations. For illustration, simulated force-length relations of a myofibril portion consisting of a sarcomere pair are presented.

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Experimental determination of sarcomere force–length relationship in type-I human skeletal muscle fibers

Cited by 67 publications

References 37 publications

Importance of the subscapularis muscle after total shoulder arthroplasty

Importance of the subscapularis muscle after total shoulder arthroplasty

On the ascent: the soleus operating length is conserved to the ascending limb of the force-length curve across gait mechanics in humans

Force–length relation of skeletal muscles: from sarcomeres to myofibril

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