Experimental design of reversed-phase high performance liquid chromatographic conditions for simultaneous determination of ibuprofen, pseudoephedrine hydrochloride, chlorpheniramine maleate, and nipagen

Applying eco‐friendly micellar liquid chromatography for the simultaneous determination of two ternary mixtures utilized for cold treatment using monolithic column

“…The innovation of the provided chromatographic methods is that, it proved to be highly superior to the comparison HPLC methods, for mixture I, it achieved lower linearity ranges that assigns high sensitivity, in addition to, consumption of lower percent of organic modifier compared to the reference methods (50 ml acetonitrile and 20 ml methanol), and the total run times not exceeds 7 min, while in the reported method [35] takes more time that reaches 13.6 min. For mixture II, it is the first isocratic method to separate PSE, IBU, and CP simply without performing exhausted gradient elution, in addition to consumption of lower percent organic modifier compared to the reference methods [36,37] that consume 60 ml, besides, it is more rapid, where the elution time reaches 16.0 min in the previous reported method. [36] The provided drugs have distinct lipophilicity that is challenging to resolve them in the same chromatographic run where, PHE, IBU, CP, and PSE have log p values of À0.69, 3.5, 3.74, and 1.3, respectively.…”

“…For mixture II, it is the first isocratic method to separate PSE, IBU, and CP simply without performing exhausted gradient elution, in addition to consumption of lower percent organic modifier compared to the reference methods [36,37] that consume 60 ml, besides, it is more rapid, where the elution time reaches 16.0 min in the previous reported method. [36] The provided drugs have distinct lipophilicity that is challenging to resolve them in the same chromatographic run where, PHE, IBU, CP, and PSE have log p values of À0.69, 3.5, 3.74, and 1.3, respectively. [39] The established methods could successfully separate both mixtures in a short chromatographic run; less than 7 min with highresolution factor in raw materials (Figures 2a,b) and their combined tablets (Figures S1 and S2).…”

Functionalized Fe3O4Magnetic Nanoparticle Potentiometric Detection Strategy versus Classical Potentiometric Strategy for Determination of Chlorpheniramine Maleate and Pseudoephedrine HCl

“…Statistical comparison was performed between the six fabricated sensors and a reported method [ 23 ] for the analysis of CPM and PSE. As the calculated t and F values were found to be less than the theoretical values, it was concluded that there was no significant difference as demonstrated in Table 7 .…”

“…Ibuprofen (IBF) with a purity of 100.05 ± 1.357 was provided from GlaxoWellcome, Egypt. The purity of the three drugs was checked by a reported method [ 23 ].…”

“…A detailed survey for the reported methods that were utilized for the analysis of CPM, PSE, and IBF has revealed that these drugs were determined either singly or in their binary mixtures by spectrophotometry [ 4 , 5 ], HPTLC [ 6 ], HPLC-MS and GC-MS [ 7 – 9 ], HPLC-UV [ 10 ], capillary electrophoresis [ 11 , 12 ], and potentiometry [ 13 – 22 ]. However, only one method was found for the simultaneous determination of the three drugs based on liquid chromatography with experimental design [ 23 ].…”