Experimental design: minimizing the number of subjects that suffer may not mean minimizing total suffering

Sedcole, J. R.

doi:10.1016/j.anbehav.2005.05.019

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…In the event that treatment and control groups experience different degrees of distress it may be possible to reduce the number of animals sub jected to high distress levels and increase those subjected to lower levels in order to maintain the desired level of statistical power. Because this opera tion will require a greater number of animals than the original calculated minimum (Sedcole 2006), it is advisable to consult a statistician to ensure that statistical power is not compromised. Similarly, the use of appropriate sequential experimental designs can result in a reduction in the numbers of animals that experience distress, as this technique allows the analysis of data as they accumulate (Waterton et al 2000).…”

Section: Sample Size Determinationmentioning

confidence: 99%

Recognition and Alleviation of Distress in Laboratory Animals

Ward¹,

Blanchard²,

Bolívar³

2008

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Section: Sample Size Determinationmentioning

confidence: 99%

Recognition and Alleviation of Distress in Laboratory Animals

Ward¹,

Blanchard²,

Bolívar³

2008

View full text Add to dashboard Cite

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Painful dilemmas: the ethics of animal-based pain research

2009

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While it has the potential to deliver important human benefits, animal-based pain research raises ethical questions, because it involves inducing pain in sentient beings. Ethical decision-making, connected with this variety of research, requires informed harm-benefit analysis, and the aim of this paper is to provide information for such an analysis. We present an overview of the different models and their consequences for animal welfare, showing that, of the many animal models available, most have a considerable welfare impact on the animal. While the usual approach to pain control through administration of analgesic substances is usually unsuitable in pain research, refinement remains an option, both within the experimental protocol and in general husbandry and handling. Drawing on the overview, we develop a discussion of the ethical acceptability of animal-based pain research against the background of the kinds of harm done to the animals involved, the potential for refinement, and the expected benefits of the research.

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Experimental design: minimizing the number of subjects that suffer may not mean minimizing total suffering

Cited by 2 publications

References 6 publications

Recognition and Alleviation of Distress in Laboratory Animals

Recognition and Alleviation of Distress in Laboratory Animals

Painful dilemmas: the ethics of animal-based pain research

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