Experimental design in pesticide extraction methods: A review

Narenderan, S. T.; Meyyanathan, S. N.; Karri, Veera Venkata Satyanarayana Reddy

doi:10.1016/j.foodchem.2019.03.045

Cited by 98 publications

(28 citation statements)

References 81 publications

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“…Nowadays, pesticide-contaminated food commodities with pesticides have caused concern all over the world. 201 Pesticides are responsible for altering an organism's growth or behavior by affecting biological systems (insects, weeds, fungi, organs, cells, enzymes, and receptors). 202 Thus, it is necessary to find ways to control the adverse effects and toxicities of pesticides.…”

Section: Pesticidesmentioning

confidence: 99%

Promising effects of gingerol against toxins: A review article

et al. 2021

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Ginger is a medicinal and valuable culinary plant. Gingerols, as an active constituent in the fresh ginger rhizomes of Zingiber officinale, exhibit several promising pharmacological properties. This comprehensive literature review was performed to assess gingerol's protective and therapeutic efficacy against the various chemical, natural, and radiational stimuli. Another objective of this study was to investigate the mechanism of anti-inflammatory, antioxidant, and antiapoptotic properties of gingerol. It should be noted that the data were gathered from in vivo and in vitro experimental studies. Gingerols can exert their protective activity through different mechanisms and cell signaling pathways.For example, these are mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kB), Wnt/β-catenin, nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE), transforming growth factor beta1/Smad3 (TGF-β1/Smad3

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Section: Pesticidesmentioning

confidence: 99%

Promising effects of gingerol against toxins: A review article

et al. 2021

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“…Quality by design and thus design of experiments have already been widely applied in the food or chemistry industries for product optimisation and process improvement [15][16][17]. Applications in the pharmaceutical field have been constantly growing in the past years: from solid dosage forms [18] to nanoparticulate systems such as liposomes, polymeric micelles or drug nanocrystals [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation

González-Fernández

Bianchera

Gasco³

et al. 2021

Pharmaceutics

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Nanotherapeutics based on biocompatible lipid matrices allow for enhanced solubility of poorly soluble compounds in the treatment of ophthalmic diseases, overcoming the anatomical and physiological barriers present in the eye, which, despite the ease of access, remains strongly protected. Micro-/nanoemulsions, solid lipid nanoparticles (SLN) or nanostructured lipid carriers (NLC) combine liquid and/or solid lipids with surfactants, improving drug stability and ocular bioavailability. Current research and development approaches based on try-and-error methodologies are unable to easily fine-tune nanoparticle populations in order to overcome the numerous constraints of ocular administration routes, which is believed to hamper easy approval from regulatory agencies for these systems. The predictable quality and specifications of the product can be achieved through quality-by-design (QbD) implementation in both research and industrial environments, in contrast to the current quality-by-testing (QbT) framework. Mathematical modelling of the expected final nanoparticle characteristics by variation of operator-controllable variables of the process can be achieved through adequate statistical design-of-experiments (DoE) application. This multivariate approach allows for optimisation of drug delivery platforms, reducing research costs and time, while maximising the understanding of the production process. This review aims to highlight the latest efforts in implementing the design of experiments to produce optimised lipid-based nanocarriers intended for ophthalmic administration. A useful background and an overview of the different possible approaches are presented, serving as a starting point to introduce the design of experiments in current nanoparticle research.

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“…The conventional strategies for optimizing the extraction and purification method through a single-factor approach have some deficiencies. They require excessive unneces-sary runs, but only give a superficial system optimum, ignoring the interaction between various factors [5]. The Plackett-Burman design (PBD) method uses a first order polynomial equation to rapidly and effectively screen the most important factors from multiple variables in a single approach [6].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Extraction or Purification Process of Multiple Components from Natural Products: Entropy Weight Method Combined with Plackett–Burman Design and Central Composite Design

Huang

Jin

et al. 2021

Molecules

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In this paper, the optimization of the extraction/purification process of multiple components was performed by the entropy weight method (EWM) combined with Plackett–Burman design (PBD) and central composite design (CCD). We took the macroporous resin purification of Astragalus saponins as an example to discuss the practicability of this method. Firstly, the weight of each component was given by EWM and the sum of the product between the componential content and its weight was defined as the comprehensive score, which was taken as the evaluation index. Then, the single factor method was adopted for determining the value range of each factor. PBD was applied for screening the significant factors. Important variables were further optimized by CCD to determine the optimal process parameters. After the combination of EWM, PBD and CCD, the resulting optimal purification conditions were as follows: pH value of 6.0, the extraction solvent concentration of 0.15 g/mL, and the ethanol volume fraction of 75%. Under the optimal conditions, the practical comprehensive score of recoveries of saponins was close to the predicted value (n = 3). Therefore, the present study provided a convenient and efficient method for extraction and purification optimization technology of multiple components from natural products.

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Experimental design in pesticide extraction methods: A review

Cited by 98 publications

References 81 publications

Promising effects of gingerol against toxins: A review article

Promising effects of gingerol against toxins: A review article

Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation

Optimization of Extraction or Purification Process of Multiple Components from Natural Products: Entropy Weight Method Combined with Plackett–Burman Design and Central Composite Design

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