Experimental depression induces renal oxidative stress in rats

Pedreáñez, Adriana; Arcaya, José Luis; Carrizo, Edgardo; Rincón, Jaimar; Viera, Ninoska; Peña, Caterina; Vargas, Renata; Mosquera, Jesús

doi:10.1016/j.physbeh.2011.06.021

Cited by 17 publications

(14 citation statements)

References 53 publications

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“…The results were expected to be similar to those in the literature (with test-retest separated by 24 h) or to those of Pedreañez et al (2011) for rats subjected to chronic swimming. We found that, after the chronic treatment period, the time values were different from those observed when the test and retest were separated by 24 h. Stressed animals treated with saline had no alterations in floating, swimming or climbing times, indicating that forced swimming, when performed on a chronic basis, is not an appropriate model for investigating behavioral changes in rats.…”

Section: Discussionsupporting

confidence: 85%

“…We found that, after the chronic treatment period, the time values were different from those observed when the test and retest were separated by 24 h. Stressed animals treated with saline had no alterations in floating, swimming or climbing times, indicating that forced swimming, when performed on a chronic basis, is not an appropriate model for investigating behavioral changes in rats. It should be pointed out that different strains of rats exhibited different behavior in the two studies: the active behavior of Sprague-Dawley rats was reduced in Pedreañez et al (2011) whereas, in the present study, Wistar behavior was constant throughout the protocol.…”

Section: Discussioncontrasting

confidence: 51%

“…The results showed that the floating, swimming and climbing times of treated rats were similar to those observed when fluoxetine was administered 24 hours before the test (acute effect). Pedreañez et al (2011), studying the effects of forced swimming as a chronic stressor, carried out fifteen 30-min forced swimming sessions and found that the animals' active behavior dropped by 84 percent between the first and last session.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Humoral Immune Response of Wistar Rats Submitted to Forced Swimming and Treated with Fluoxetine

Fernandes¹,

Venâncio²,

Estanislau³

2012

Effects of Antidepressants

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Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Humoral Immune Response of Wistar Rats Submitted to Forced Swimming and Treated with Fluoxetine

Fernandes¹,

Venâncio²,

Estanislau³

2012

Effects of Antidepressants

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“…In the On TARGET trial of 28,384 participants, ARBs reduced MMSE decline in people with baseline macroalbuminuria [197]. ARBs also decreased depressive symptoms, [201;202] possibly because brain inflammation plays an important role in the pathophysiology of mood disorders [203;204]. …”

Section: Antihypertensive Therapy and Cognitionmentioning

confidence: 99%

Cognition and Hemodynamics

Novak

2012

Curr Cardiovasc Risk Rep

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The relationship between cerebral hemodynamics and cognitive performance has increasingly become recognized as a major challenge in clinical practice for older adults. Both diabetes and hypertension worsen brain perfusion and are major risk factors for cerebrovascular disease, stroke and dementia. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure–perfusion–cognition relationships. Endothelial dysfunction and inflammation, microvascular disease, and mascrovascular disease affect cerebral hemodynamics and play an important role in pathohysiology and severity of multiple medical conditions, presenting as cognitive decline in the old age. Therefore, the identification of cerebrovascular vascular reactivity as a new therapeutic target is needed for prevention of cognitive decline late in life.

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“…Oxidative stress has been reported to modulate several behaviors including learning and memory function (Alzoubi et al, 2012; Alzoubi et al, 2013a; Alzoubi et al, 2013b), anxiety- (Allam et al, 2013; Hovatta et al, 2005; Masood et al, 2009; Salim et al, 2010a; Salim et al, 2011), depression- (Brocardo et al, 2012; Leonard and Maes, 2012; Pedreanez et al, 2011), mania- (Macedo et al, 2013), nociceptive- (Arcan et al, 2012) and schizophrenia- (Rao et al, 2012) like behaviors. We also measured the effect of social defeat-induced stress on oxidative stress within three critical brain areas, considered vital for depression, anxiety and cognition, namely, hippocampus, amygdala and prefrontal cortex (McEwen et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress

Patki¹,

Solanki²,

Atrooz³

et al. 2013

Brain Research

328

213

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In the present study, we have examined the behavioral and biochemical effect of induction of psychological stress using a modified version of the resident-intruder model for social stress (social defeat). At the end of the social defeat protocol, body weights, food and water intake were recorded, depression and anxiety-like behaviors as well as learning-memory function was examined. Biochemical analysis including oxidative stress measurement, inflammatory markers and other molecular parameters, critical to behavioral effects were examined. We observed a significant decrease in the body weight in the socially defeated rats as compared to the controls. Furthermore, social defeat increased anxiety-like behavior and caused memory impairment in rats (P<0.05). Socially defeated rats made significantly more errors in long term memory tests (P<0.05) as compared to control rats. Furthermore, brain extracellular signal-regulated kinase-1/2 (ERK1/2), and an inflammatory marker, interleukin (IL)-6 were activated (P<0.05), while the protein levels of glyoxalase (GLO)-1, glutathione reductase (GSR)-1, calcium/calmodulin-dependent protein kinase type (CAMK)-IV, cAMP-response-element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) were significantly less (P<0.05) in the hippocampus, but not in the prefrontal cortex and amygdala of socially defeated rats, when compared to control rats. We suggest that social defeat stress alters ERK1/2, IL-6, GLO1, GSR1, CAMKIV, CREB, and BDNF levels in specific brain areas, leading to oxidative stress-induced anxiety-depression-like behaviors and as well as memory impairment in rats.

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Experimental depression induces renal oxidative stress in rats

Cited by 17 publications

References 53 publications

Evaluation of the Humoral Immune Response of Wistar Rats Submitted to Forced Swimming and Treated with Fluoxetine

Evaluation of the Humoral Immune Response of Wistar Rats Submitted to Forced Swimming and Treated with Fluoxetine

Cognition and Hemodynamics

Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress

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