2021
DOI: 10.1002/lpor.202100425
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Experimental Demonstration of Genetic Algorithm Based Metalens Design for Generating Side‐Lobe‐Suppressed, Large Depth‐of‐Focus Light Sheet

Abstract: Light-sheet fluorescence microscopy (LSFM), sectioning biological samples by illuminating a thin slice of fluorescently labelled live cells or tissues typically with a Bessel beam, requires dithering the beam to form a two-dimensional (2D) light sheet. It usually suffers from severe phototoxicity and low signal-to-noise ratio (SNR) mainly caused by the side-lobe illumination generating unfavorable bio-fluorescence from the adjacent tissues. Here, the first proof-of-concept experimental implementation of geneti… Show more

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Cited by 28 publications
(10 citation statements)
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References 69 publications
(56 reference statements)
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“…Genetic algorithm (GA, sometimes named evolutionary algorithm) is one of the most frequently used evolutionary computation strategies. Additionally, GA has greatly promoted the inverse design of metasurfaces in recent years, such as a metalens, a terahertz quarter-wave plate, programmable metamaterials, and subwavelength lattice optics …”
Section: Ai For Meta-opticsmentioning
confidence: 99%
See 1 more Smart Citation
“…Genetic algorithm (GA, sometimes named evolutionary algorithm) is one of the most frequently used evolutionary computation strategies. Additionally, GA has greatly promoted the inverse design of metasurfaces in recent years, such as a metalens, a terahertz quarter-wave plate, programmable metamaterials, and subwavelength lattice optics …”
Section: Ai For Meta-opticsmentioning
confidence: 99%
“…Genetic algorithm (GA, sometimes named evolutionary algorithm) 162 is one of the most frequently used evolutionary computation strategies. Additionally, GA has greatly promoted the inverse design of metasurfaces in recent years, such as a metalens, 163 a terahertz quarter-wave plate, 164 programmable metamaterials, 165 and subwavelength lattice optics. 166 Figure 17a demonstrates a general working flow of GA. GA usually takes a set of randomly generated solutions or artificially set initial points as the first generation of the population.…”
Section: Gradient-free Evolutionary Computationmentioning
confidence: 99%
“…2a, which includes three main steps. The first is Search, which can yield the optimal height distribution by combining genetic algorithm (GA) and Hook-Jeeves algorithm (HJA) [48][49][50] to avoid local minima and speed up the convergence as well. The second is Smooth, which can remove the high aspectratio structures in the lens.…”
Section: Design Of Amdlsmentioning
confidence: 99%
“…2a, which includes three main steps. The first is Search, which can yield the optimal height distribution by combining genetic algorithm (GA) and Hook-Jeeves algorithm (HJA) [46][47][48] to avoid local minima and speed up the convergence as well. The second is Smooth, which can remove the high aspect-ratio structures in the lens.…”
Section: Design Of Amdlsmentioning
confidence: 99%