Experimental creep behavior of porcine liver under indentation with laparoscopic grasper for MIS applications

Cai, Chengmo; Yu, Qing-Yuan; Li, Wei; Zheng, Jing; Zhou, Zhongrong

doi:10.1016/j.bsbt.2017.06.002

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Moreover, stress relaxation and creep tests are the widespread measuring techniques for viscoelastic materials’ time-dependent behavior of liver tissues (Cai et al 2017 ). Such tests have been utilized in combination or separately, enabling complete and precise data on the time-dependent behavior of viscoelastic samples (Bartolini et al 2018 ).…”

Section: Challenges and Outlookmentioning

confidence: 99%

Mechanical properties of human hepatic tissues to develop liver-mimicking phantoms for medical applications

Lemine,

Ahmad,

Al-Thani

et al. 2023

Biomech Model Mechanobiol

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Using liver phantoms for mimicking human tissue in clinical training, disease diagnosis, and treatment planning is a common practice. The fabrication material of the liver phantom should exhibit mechanical properties similar to those of the real liver organ in the human body. This tissue-equivalent material is essential for qualitative and quantitative investigation of the liver mechanisms in producing nutrients, excretion of waste metabolites, and tissue deformity at mechanical stimulus. This paper reviews the mechanical properties of human hepatic tissues to develop liver-mimicking phantoms. These properties include viscosity, elasticity, acoustic impedance, sound speed, and attenuation. The advantages and disadvantages of the most common fabrication materials for developing liver tissue-mimicking phantoms are also highlighted. Such phantoms will give a better insight into the real tissue damage during the disease progression and preservation for transplantation. The liver tissue-mimicking phantom will raise the quality assurance of patient diagnostic and treatment precision and offer a definitive clinical trial data collection.

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Section: Challenges and Outlookmentioning

confidence: 99%

Mechanical properties of human hepatic tissues to develop liver-mimicking phantoms for medical applications

Lemine,

Ahmad,

Al-Thani

et al. 2023

Biomech Model Mechanobiol

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“…The use of large spherical indenters facilitates contact detection on extremely soft samples (hydrogels [72], cartilage, scaffolds) by providing larger contact stiffness and averages surface and structural inhomogeneity. The penetrations seen in bioindentation are usually in the range of ten to several hundred micrometers, thus testing a large volume of tissue rather than single cells [73]. The applications of the bioindenter are very wide.…”

Section: Nanoindentation In Biological Materialsmentioning

confidence: 99%

Comparative Analysis Carried Out on Modern Indentation Techniques for the Measurement of Mechanical Properties: A Review

Rouf¹,

Altaf²,

Malik³

et al. 2021

Post-Transition Metals

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Nowadays many indentation techniques are being commonly employed for determining some mechanical properties (harness, elastic modulus, toughness, etc.) using simple method of measuring the indentation depth. On the basis of measurement of depth of penetration, indentation technique has be classified into major categories i.e. microindentation and nanoindentation. Nanoindentation technique uses indirect method of determining the contact area as the depth of penetration is measured in nanometers, while in conventional indentation the area in contact is measured by elementary measurement of the residual area after the indenter is removed from the specimen. Dynamic hardness is the best result of dynamic indentation which can be expressed as the ratio of energy consumed during a rapid indentation to the volume of indentation. The parameter which are taken into consideration are indentation depth, contact force, contact area, mean contact pressure.

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“…Chen et al [131] showed the microstructural changes occurring with increased loading and failure. Cai et al [132] explored the creep behavior of the liver under indentations with a laparoscopic grasper used in minimally-invasive surgery.…”

Section: Liver Biomechanical Characteristicsmentioning

confidence: 99%

Liver Bioreactor Design Issues of Fluid Flow and Zonation, Fibrosis, and Mechanics: A Computational Perspective

Rezania

Coombe

Tuszyński

2020

JFB

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Tissue engineering, with the goal of repairing or replacing damaged tissue and organs, has continued to make dramatic science-based advances since its origins in the late 1980’s and early 1990’s. Such advances are always multi-disciplinary in nature, from basic biology and chemistry through physics and mathematics to various engineering and computer fields. This review will focus its attention on two topics critical for tissue engineering liver development: (a) fluid flow, zonation, and drug screening, and (b) biomechanics, tissue stiffness, and fibrosis, all within the context of 3D structures. First, a general overview of various bioreactor designs developed to investigate fluid transport and tissue biomechanics is given. This includes a mention of computational fluid dynamic methods used to optimize and validate these designs. Thereafter, the perspective provided by computer simulations of flow, reactive transport, and biomechanics responses at the scale of the liver lobule and liver tissue is outlined, in addition to how bioreactor-measured properties can be utilized in these models. Here, the fundamental issues of tortuosity and upscaling are highlighted, as well as the role of disease and fibrosis in these issues. Some idealized simulations of the effects of fibrosis on lobule drug transport and mechanics responses are provided to further illustrate these concepts. This review concludes with an outline of some practical applications of tissue engineering advances and how efficient computational upscaling techniques, such as dual continuum modeling, might be used to quantify the transition of bioreactor results to the full liver scale.

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Experimental creep behavior of porcine liver under indentation with laparoscopic grasper for MIS applications

Cited by 4 publications

References 30 publications

Mechanical properties of human hepatic tissues to develop liver-mimicking phantoms for medical applications

Mechanical properties of human hepatic tissues to develop liver-mimicking phantoms for medical applications

Comparative Analysis Carried Out on Modern Indentation Techniques for the Measurement of Mechanical Properties: A Review

Liver Bioreactor Design Issues of Fluid Flow and Zonation, Fibrosis, and Mechanics: A Computational Perspective

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