Experimental Coxiella burnetii Infection in Pregnant Goats: a Histopathological and Immunohistochemical Study

Sánchez, J.; Souriau, Armel; Buendía, A. J.; Arricau‐Bouvery, Nathalie; Martínez, Carlos; Salinas, J.; Rodolakis, Annie; Navarro, J. A.

doi:10.1016/j.jcpa.2006.06.003

Cited by 79 publications

(91 citation statements)

References 34 publications

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“…A limited number of studies have been performed examining the presence of C. burnetii in bovine, ovine, and caprine aborts in different countries (Sanchez et al 2006;Szeredi et al 2006;Jensen et al 2007;Hazlett et al 2013). Sheep aborts were positive for the presence of C. burnetii in 3.7% of cases in Germany (Plagemann 1989), 1% in Switzerland (Chanton-Greutmann et al 2002), and 2% in Hungary (Szeredi et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…For infection with this agent, IHC has been applied more on the mothers and placentas than on foetal organs (Bildfell et al 2000;Sanchez et al 2006;Jensen et al 2007;Muskens et al 2012). Due to the fact that PCR revealed C. burnetii positivity in nine cases versus only four when using IHC in a study population of 100 bovine placentas with foetal abort viscera, Muskens et al (2012) advanced the idea that IHC may be less sensitive than PCR.…”

Section: Discussionmentioning

confidence: 99%

“…burnetii primarily infects the trophoblasts in the placenta (Baumgartner and Bachmann 1992;Sanchez et al 2006). It has been proposed that C. burnetii is transported from the mother to the foetus by macrophages (Bildfell et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Coxiella burnetii is an obligatory intracellular pathogen that causes a disease that leads to abortion in sheep, goats, and cattle (Rady et al 1985;Maurin and Raoult 1999;Bildfell et al 2000;Sanchez et al 2006). Such abortions may occur along with other problems including low birth weight, death of new-born cattle, failure to expel the placenta, endometritis, and infertility (Plommet et al 1973;Behymer et al 1976;Bildfell et al 2000).…”

mentioning

confidence: 99%

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Determination of Coxiella burnetii in bovine foetuses using PCR and immunohistochemistry

Özkaraca¹,

Çeribaşı²,

Çeribaşı³

et al. 2016

Vet. Med. - Czech

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This study was aimed at detection of Coxiella burnetii in bovine foetuses using polymerase chain reaction (PCR) and immunohistochemistry (IHC) and at an estimation of its frequency in Eastern Turkey. Stamp, Giemsa, and Gimenez stains were used in addition to PCR and IHC to determine the presence of C. burnetii in samples from 70 bovine foetuses. While the staining methods did not detect the agent by direct visualisation of C. burnetii on smears, PCR and IHC identified its presence in two of the foetuses. The distribution of antigens in these two foetuses was, in decreasing order of concentration, in the spleen, the thymus, the lungs, the liver, and the kidneys. We conclude that C. burnetii diagnosis in bovine foetuses can be reliably performed using PCR and IHC. In addition, the frequency of 1.42% of C. burnetii positivity in bovine foetuses reported here was the first time that the presence of this agent was determined in Eastern Turkey.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Determination of Coxiella burnetii in bovine foetuses using PCR and immunohistochemistry

Özkaraca¹,

Çeribaşı²,

Çeribaşı³

et al. 2016

Vet. Med. - Czech

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“…Several experimental studies confirmed that infections with Chlamydophila abortus (Rodolakis et al 1984), Coxiella burnetii (Sánchez et al 2006), bovine viral diarrhea virus (Løken and Bjerkåss 1991), caprine herpesvirus type 1 (Tempesta et al 2004), Toxoplasma gondii, Neospora caninum and Sarcocystis sp. (Dubey et al 1986, Lindsay et al 1995, Buxton 1998) may result in an intrauterine embryonic and fetal death, abortion and delivery of dead or week kids.…”

Section: Introductionmentioning

confidence: 93%

Multivariate model for the assessment of risk of fetal loss in goat herds

Czopowicz¹,

Kaba²,

Szaluś‐Jordanow³

et al. 2012

Polish Journal of Veterinary Sciences

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The observational study was carried out in a population of Polish breeding goats in 2007 to determine the prevalence of fetal loss and identify risk factors contributing to its occurrence. The multivariate model allowing to predict the risk of the occurrence of fetal loss in a herd in a study population was developed. Data on the occurrence of fetal loss, as well as of 28 hypothesized risk factors were collected from goat owners using standardized questionnaire during face-to-face reviews on farms. Moreover, data on the herd-level seroprevalence of four abortifacient infections -Chlamydophila abortus, Leptospira spp., BVDV-1 and Neospora caninum -were included in the final analysis. Fetal loss was reported as occurring often in 12 of 49 goat herds (24.5%). The relationship between the hypothesized risk factors and the occurrence of fetal loss was verified in the multivariate logistic regression (α=0.05). Final analysis yielded four risk factors: regular veterinary supervision at least twice a year (OR 0.188; CI 95% 0.054 -0.656), frequent occurrence of injuries and fractures (OR 3.172; CI 95% 1.081 -9.310), frequent occurrence of respiratory signs in adult goats (OR 4.848; CI 95% 1.353 -17.377) and presence of antibodies to C. abortus in a herd (OR 58.116; CI 95% 1.369 -2466.438). The accuracy of the multivariate model was analyzed using receiver operating characteristic (ROC) curve technique. Area under the curve was 0.895 (CI 95% 0.801-0.981). For optimal cut-off value of 0.20-0.35 the multivariate model had sensitivity of 75.00% and specificity of 89.19% in predicting fetal loss in a herd.

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Coxiella burnetiiInfection

Ruiz‐Fons

2012

Infectious Diseases of Wild Mammals and Birds in Europe

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Experimental Coxiella burnetii Infection in Pregnant Goats: a Histopathological and Immunohistochemical Study

Cited by 79 publications

References 34 publications

Determination of Coxiella burnetii in bovine foetuses using PCR and immunohistochemistry

Determination of Coxiella burnetii in bovine foetuses using PCR and immunohistochemistry

Multivariate model for the assessment of risk of fetal loss in goat herds

Coxiella burnetiiInfection

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