1936
DOI: 10.1097/00005053-193607000-00020
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Experimental Convulsions Induced by Administration of Thujone

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Cited by 8 publications
(9 citation statements)
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“…It has, thus, been hypothesised that the ketone bodies play a crucial role in the antiepileptic properties seen in KD. Studies involving administration of acetone and acetoacetate in animal models including rabbits, mice and rats have shown protection against induced seizures to varying degrees (45)(46)(47)(48) . In our study, we showed MCTD-related antiepileptic effects that were poorly correlated with relative changes in serum BHB concentrations.…”
Section: Discussionmentioning
confidence: 99%
“…It has, thus, been hypothesised that the ketone bodies play a crucial role in the antiepileptic properties seen in KD. Studies involving administration of acetone and acetoacetate in animal models including rabbits, mice and rats have shown protection against induced seizures to varying degrees (45)(46)(47)(48) . In our study, we showed MCTD-related antiepileptic effects that were poorly correlated with relative changes in serum BHB concentrations.…”
Section: Discussionmentioning
confidence: 99%
“…In trying to understand a ketogenic diet’s therapeutic mechanism, many laboratories have investigated whether ketone bodies at pharmacological doses have intrinsic anticonvulsant properties. The anticonvulsant properties of acetoacetate were first reported by Keith (1935) where its administration in rabbits protected against thujone‐induced seizures. In agreement with this early report, Rho and colleagues found that intraperitoneally administered acetoacetate and acetone, but not β‐hydroxybutyrate, protected against seizures in the Frings audiogenic seizure‐susceptible juvenile mouse (Rho et al.…”
Section: Ketone Bodies: Anticonvulsant Propertiesmentioning
confidence: 99%
“…Studies dating back to the 1930s also support the direct antiseizure effects of ketones [15,16]. In mice, acetone and acetoacetate raise seizure thresholds, resulting in fewer seizures [15,16]. Although BHB did not appear to contribute to antiseizure effects in these earlier studies, more recent studies indicate that BHB probably does play a direct antiseizure role, and that its effects may have been previously missed for methodological reasons [11].…”
Section: Ketones As Key Mediators Of Seizure Controlmentioning
confidence: 86%
“…Studies dating back to the 1930s also support the direct antiseizure effects of ketones [15,16]. In mice, acetone and acetoacetate raise seizure thresholds, resulting in fewer seizures [15,16].…”
Section: Ketones As Key Mediators Of Seizure Controlmentioning
confidence: 94%