Experimental chronic compression on the spinal cord of the rabbit by ectopic bone formation in the ligamentum flavum with bone morphogenetic protein

Mimatsu, Kentaro; Kishi, Shinichi; Hashizume, Yoshio

doi:10.1038/sj.sc.3100533

Cited by 42 publications

(23 citation statements)

References 8 publications

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“…The proliferation of cartilaginous tissue triggers the ossification. Fibronectin, bone morphogenetic protein and transforming growth factor-beta may also play a role in the genesis of OLF 4,5,9,11) . However, we did not perform the histological examination.…”

Section: Discussionmentioning

confidence: 99%

Thoracic Myelopathy Caused by Ossification of the Ligamentum Flavum

Hur

Lee

et al. 2009

J Korean Neurosurg Soc

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Objectives : Ossification of the ligamentum flavum (OLF) is a rare cause of thoracic myelopathy. The aim of this study was to identify factors associated with the surgical outcome on the basis of preoperative clinical and radiological findings. Methods : Data obtained in 26 patients whot underwent posterior decompression for thoracic myelopathy, caused by thoracic OLF, were analyzed retrospectively. Patient age, duration of symptoms, OLF type, preoperative and postoperative neurological status using the Japanese Orthopedic Association (JOA) scoring system, surgical outcome, and other factors were reviewed. We compared the various factors and postoperative prognosis. All patients had undergone decompressive laminectomy and excision of the OLF. Results : Using the JOA score, the functional improvement was excellent in 8 patients, good in 14, fair in 2, and unchanged in 2. A mean preoperative JOA score of 6.65 improved to 8.17 after an average of 27.3 months. According to our analysis, age, gender, duration of symptoms, the involved spinal level, coexisting spinal disorders, associated trauma, intramedullary signal change, and dural adhesions were not related to the surgical outcome. However, the preoperative JOA score and type of OLF were the most important predictors of the surgical outcome. Conclusion : Early diagnosis and sufficient surgical decompression could improve the functional prognosis for thoracic OLF. The postoperative results were found to be significantly associated with the preoperative severity of myelopathy and type of OLF.

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Section: Discussionmentioning

confidence: 99%

Thoracic Myelopathy Caused by Ossification of the Ligamentum Flavum

Hur

Lee

et al. 2009

J Korean Neurosurg Soc

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“…However, this characteristic of BMP-2 or BMP-7 might also be harmful. In previous studies new bone formation induced by BMP-2 in the ligamentum flavum resulted in flattening of the spinal cord [36]. Additionally, Hoshi et al [19] was able to show that ossifications of the spinal ligaments induced by BMP-2 can even lead to spinal cord compression.…”

Section: Introductionmentioning

confidence: 94%

Dose-dependent effects of combined IGF-I and TGF-β1 application in a sheep cervical spine fusion model

et al. 2002

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Combined IGF-I and TGF-β1 application by a poly-(D,Llactide) (PDLLA) coated interbody cage has proven to promote spine fusion. The purpose of this study was to determine whether there is a dosedependent effect of combined IGF-I and TGF-β1 application on intervertebral bone matrix formation in a sheep cervical spine fusion model. Thirty-two sheep underwent C3/4 discectomy and fusion. Stabilisation was performed using a titanium cage coated with a PDLLA carrier including no growth factors in group 1 (n=8), 75 µg IGF-I plus 15 µg TGF-β1 in group 2 (n=8), 150 µg IGF-I plus 30 µg TGF-β1 in group 3 (n=8) and 300 µg IGF-I plus 60 µg TGF-β1 in group 4 (n=8). Blood samples, body weight and temperature were analysed. Radiographic scans were performed pre-and postoperatively and after 1, 2, 4, 8, and 12 weeks. At the same time points, disc space height and intervertebral angle were measured. After 12 weeks, the animals were killed and fusion sites were evaluated using quantitative computed tomographic (CT) scans to assess bone mineral density, bone mineral content and bony callus volume. Biomechanical testing was performed and range of motion, and

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“…In frü-heren Untersuchungen konnte gezeigt werden, dass BMP-2-induzierte Ossifikationen im Lig. flavum zu einer Verdrängung des Myelons führten [41]. Hoshi [19] wies darüber hinaus nach, dass die BMP-2-induzierte Ossifikation spinaler Ligamente, speziell des Lig.…”

Section: Wachstumsfaktorenunclassified

Experimentelle Spondylodese der Schafshalswirbelsäule

Kandziora

Scholz

Pflugmacher

et al. 2002

Chirurg

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PDLLA coating of cervical spine interbody fusion cages as a delivery system for growth factors was effective and safe. In comparison to the collagen sponge carrier, the new PDLLA carrier system was able to improve results of interbody bone matrix formation. Both growth factors (BMP-2 and combined IGF-I and TGF-beta1) significantly accelerated results of interbody fusion. Based on these preliminary results, the combined IGF-I/TGF-beta1 application yields results equivalent to BMP-2 application at an early time in anterior sheep cervical spine fusion.

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Experimental chronic compression on the spinal cord of the rabbit by ectopic bone formation in the ligamentum flavum with bone morphogenetic protein

Cited by 42 publications

References 8 publications

Thoracic Myelopathy Caused by Ossification of the Ligamentum Flavum

Thoracic Myelopathy Caused by Ossification of the Ligamentum Flavum

Dose-dependent effects of combined IGF-I and TGF-β1 application in a sheep cervical spine fusion model

Experimentelle Spondylodese der Schafshalswirbelsäule

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