EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCH Evaluation of the impact of radical tumor resection in lung cancer patients on the activity of selected antioxidant enzymes

Misiak, Piotr; Rzepkowska-Misiak, Beata; Wcisło, Szymon; Dziwińska, Katarzyna; Malinowska, Katarzyna; Majsterek, Ireneusz

doi:10.5114/kitp.2014.47342

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…A reduced activity of the antioxidative barrier was also proven in other diseases. Misiak et al (2014) showed a decreased activity of SOD, CAT and GPx in patients with lung cancer [34]. Radical tumor resection caused an increased activity of GPx and CAT, as well as total antioxidative status.…”

Section: Complexes Amentioning

confidence: 94%

Antioxidative assessment of new trans palladium(II) complexes in head and neck cancer

et al. 2019

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Background: The head and neck neoplasms stand for 6% of all malignant neoplasms worldwide. The chemotherapy has limited use due to the tumor biological properties (in majority of cases moderately and poorly differentiated squamous cell carcinoma). The fundamental molecule used in the treatment is cisplatin and its derivates, that can be associated with fluorouracil. The new chemotherapeutic agents are not in common use during the treatment of head and neck malignancies. However, use of low molecular weight complexes Pd(II) have the potential to be more effective in therapy. Material and Methods: Fifty-one patients, 30 men and 21 women (aged 52.9 ± 12.1 years) with head and neck cancer were included in the study. Fifty-one healthy subjects, 31 men and 20 women, (aged 54.1 ± 14.7 years) years formed the control group. Antioxidant enzymes, superoxide dismutase, and catalase activities in erythrocytes were examined. Results: The increases level of antioxidant enzymes were seen in blood sample from patients with head and neck cancer after incubation with Pd(II) complex.. For that group we obtained statistically significant result p = <0.001 Discussion: That project may contribute to the development of new more efficient head and neck cancer treatment strategies. In our opinion, the results can be used in the future to develop a valuable prognostic marker of the disease. This is important because the initial phase of cancer is asymptomatic. The search for factors involved in pathogenesis translates into economic benefits and make therapy more effectiveness through reduce treatment expenses.

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Section: Complexes Amentioning

confidence: 94%

Antioxidative assessment of new trans palladium(II) complexes in head and neck cancer

et al. 2019

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“…In non-small cell lung cancer (NSCLC), the first choice of treatment is surgery [1,2]. Nowadays, despite the increase in the number of patients undergoing surgery with advances in early diagnosis and surgical methods, this rate is still 15-25% [3,4].…”

Section: Introductionmentioning

confidence: 99%

Comparison of survival results of patients with T0 and T1-2-3 in pathological T staging in patients with non-small cell lung cancer who underwent surgery after neoadjuvant treatment

Kermenli

Melek

Bayram

et al. 2020

kitp

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Aim: In this study, we aimed to compare the survival results of patients who underwent neoadjuvant treatment with NSCLC between March 1997 and August 2014 and were found to have T0N0 and T1-2-3/N0. Material and methods: A hundred ninety-five patients who had complete neoadjuvant therapy, complete lung resection and lymph node dissection, and pathologically diagnosed as T0 or T1-2-3/N0, M0 were included in the study. Results: Of the 195 patients included in the study, 181 were male, 14 were female and the mean age of the patients was 57.9. The mean age of the groups was as follows: group 1: 58.1, group 2: 57.7, group 3: 59.7 and group 4: 56.8. In our series the most common complication was atelectasis (n = 19). Others were prolonged air leak (n = 16), pneumonia (n = 12), apical pleural space (n = 6), wound infection (n = 3), cardiac problems (n = 3), hematoma (n = 3), bronchopleural fistula (n = 3), empyema (n = 2), chylothorax (n = 1). The 5-year survival rate for patients in the T0N0 group was 76.3%. This rate was 71.8% in group 2, 63.6% in group 3 and 44.1% in group 4. Conclusions: Survival was found to be better in patients who underwent surgery after neoadjuvant therapy and had a complete pathological response. We believe that we can provide better results with the increase in the number of cases detected as TxN0 after the neoadjuvant treatment and prolongation of the follow-up period.

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EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCH Evaluation of the impact of radical tumor resection in lung cancer patients on the activity of selected antioxidant enzymes

Cited by 2 publications

References 10 publications

Antioxidative assessment of new trans palladium(II) complexes in head and neck cancer

Antioxidative assessment of new trans palladium(II) complexes in head and neck cancer

Comparison of survival results of patients with T0 and T1-2-3 in pathological T staging in patients with non-small cell lung cancer who underwent surgery after neoadjuvant treatment

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