Experimental Carcinoma of the Gallbladder

Petrov, N. N.; Krotkina, N.

doi:10.1097/00000658-194702000-00010

Cited by 45 publications

(9 citation statements)

References 2 publications

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“…Consistent with this is the presence of gallstones in 85% of our patients, mostly in females (52%). This is reported in other studies as well [12], The presence of gallstones may provoke inflamma tion and chronic trauma, inducing epithelial dysplasia and a consequent predisposition to carcinoma [13,14], Petrov's [ 15] experimental study as well as other investi gations support this view [ 16], Of course, a wide variety of other causes have been proposed including radiation, sex hormones, occupational exposure [ 17], or even an anoma lous pancreaticobiliary duct union [18], Regardless of the advent of newer diagnostic proce dures, carcinoma of the gallbladder is still usually found at laparotomy, and many times only at pathological exami nation. This is especially true for cases that underwent routine cholecystectomy for gallstones and where the his tological examination revealed carcinoma.…”

Section: Discussionsupporting

confidence: 56%

Carcinoma of the Gallbladder: Diagnosis, Treatment, Prognosis

Watemberg¹,

Avrahami²,

Landau³

et al. 1993

Dig Surg

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Despite modern imaging techniques, the majority of gallbladder cancers are recognized at the time of laparotomy, when curative procedures are rarely possible. Predisposing factors include old age, female sex and cholelithiasis. Abdominal pain, vomiting, anorexia, weight loss and jaundice are the most prevalent signs and symptoms. The nonspecific clinical picture combined with low sonographic diagnostic value make preoperative diagnosis unlikely. The very low survival rates, with or without surgery, dictate a more palliative approach. Palliation includes primarily the relief of pain, jaundice and intestinal obstruction. Between 1987 and 1992, we have treated 21 patients with gallbladder carcinoma. The following paper reviews these cases in light of the current literature.

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Section: Discussionsupporting

confidence: 56%

Carcinoma of the Gallbladder: Diagnosis, Treatment, Prognosis

Watemberg¹,

Avrahami²,

Landau³

et al. 1993

Dig Surg

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“…Vol. 8 the liver was extcnsively replared by yellowgiay tumor that completely suriounded and involved the gallbladder. T h e lumen 01 the gallbladder ( Fig.…”

Section: Cancer July-augzirt 1955mentioning

confidence: 99%

“…Desforges VOl. 8 that involved the gallbladder, liver, arid main bile ducts. It was riot determined whether the tumors arose primarily in the liver, bile ducts, or gallbladder or iridependently in one or more of these locations.…”

mentioning

confidence: 99%

“…Nelson and Woodard recently reported that two dogs fed o-aminoazotoluene for thirty to sixty-two months deveIoped adenocarcinomas 689 698 CANCER July-August 1955 VOl. 8 that involved the gallbladder, liver, arid main bile ducts. It was riot determined whether the tumors arose primarily in the liver, bile ducts, or gallbladder or iridependently in one or more of these locations.…”

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confidence: 99%

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Carcinoma of the gallbladder the experimental induction of primary

Fortner

1955

Cancer

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“…Experimental work in this regard has been largely limited to implantation of foreign bodies, some impregnated with known carcinogens, into the gallbladders of animals. The effects of sterile glass tubes or similar tubes containing radium implanted in the gallbladder lumen of guinea pigs were studied by Petrov and Krotkina (1947).…”

Section: Incidence Etiology and Preventionmentioning

confidence: 91%

A reappraisal of primary gallbladder carcinoma

Neel

Hammond

1970

Journal of Surgical Oncology

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A 10‐year experience with 14 patients with primary carcinoma of the gallbladder encountered in a typical community hospital has been reviewed. Abdominal discomfort in its many manifestations occurred in all patients, with chronic pain of long duration frequently being noted. Six patients were jaundiced. Twelve had documented cholelithiasis. Histologic examination revealed adenocarcinoma in all instances. One patient is alive and well at 3 years; survival of the remaining patients was from 9 days to 25 months. Primary carcinoma of the gallbladder occurs in more than 1% of surgically removed gallbladders. The disease is largely one of elderly persons with chronic calculous cholecystitis. Not only will it be seen with increasing frequency as life expectancy increases, but also it is preventable. Improvement in treatment can thus be initiated by prophylactic removal of diseased gallbladders in otherwise healthy persons. Malignancy may be obscured in those patients presenting with acute cholecystitis eluding surgeon and pathologist alike. These cases, as well as all early malignancies, are diagnosed only by careful histologic examination. Therefore, all gallbladders should be opened and examined by the surgeon in the operating room. Suspicious areas should be evaluated histologically by frozen section so that extension of the operation to include removal of adjacent hepatic parenchyma and performance of an extensive regional lymphadenectomy can be undertaken if cancer is found. By routinely considering every older patient who comes to cholecystectomy as suspect of harboring gallbladder cancer, survival may well be improved.

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Experimental Carcinoma of the Gallbladder

Cited by 45 publications

References 2 publications

Carcinoma of the Gallbladder: Diagnosis, Treatment, Prognosis

Carcinoma of the Gallbladder: Diagnosis, Treatment, Prognosis

Carcinoma of the gallbladder the experimental induction of primary

A reappraisal of primary gallbladder carcinoma

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