Experimental brain tumours induced in rats by nitrosourea derivatives

Evaluation of ENU-Induced Gliomas in Rats: Nomenclature, Immunochemistry, and Malignancy

“…Oligodendrogliomas and mixed gliomas are the most commonly described brain tumors (5,9,12,19,23,24,26,32,34,35,37). Other histologic types reported included astrocytomas (5,10,12,17,23,26,32,35), ependymomas (8,9,12,14,21,35), anaplastic or pleomorphic gliomas (11,12,14,16,21,34,35), gliosarcomas (12), glioependymomas (12,23,24), glioblastomas (5,9,21,29,35), spongioblastomas (37), neuroblastomas (10), medulloblastomas (10), and meningiomas (5,10,12,23). Tumors with malignant changes have sometimes been designated by prefixing the tumor type with the term &dquo;anaplastic&dquo; or &dquo;pleomorphic&dquo; (9,…”

“…Other histologic types reported included astrocytomas (5,10,12,17,23,26,32,35), ependymomas (8,9,12,14,21,35), anaplastic or pleomorphic gliomas (11,12,14,16,21,34,35), gliosarcomas (12), glioependymomas (12,23,24), glioblastomas (5,9,21,29,35), spongioblastomas (37), neuroblastomas (10), medulloblastomas (10), and meningiomas (5,10,12,23). Tumors with malignant changes have sometimes been designated by prefixing the tumor type with the term &dquo;anaplastic&dquo; or &dquo;pleomorphic&dquo; (9,11,12,35). The tumors appear to originate from hyperplastic cells first observed at 30 days of age in the subependymal cell plate and periventricular white matter and from small foci of oligodendroglia in the cortex and basal ganglia (14,15,17,26,28).…”