Experimental Black Tongue of Dogs and Its Relation to Pellagra

Mouth Lesions Associated with Dietary Deficiencies in Monkeys

“…However, to our knowledge, the extension of these lesiorns to the buccal or labial mucosa has not been recorded. These mucosal lesions observed in monkeys vary considerably from those described in canine blacktongue (18).…”

The Blacktongue-Preventive Value of 7 Foodstuffs

“…These experiments have been carried out on the dog, since canine blacktongue and human pellagra may be regarded as analogous conditions (1,2). Stu,dies of the pellagra-preventive potency of 38 foodstuffs have been reported (1,3,4).…”

“…The general method of conducting these experiments has been described in previous publications of this series (2,5). As in the studies previously reported, the basic diet used has been our blacktongue-producing diet no.…”

“…Then the other ingredients were well stirred in and the total weight was brought to 2,400 grams with water (so that 1 gram represented 1 calorie), and the finished mixture was served to the dog in suitable portions. 2 The variety known as the California black-eyed pea.…”

Nutritional Adequacy, Nutrient Availability and Needs

“…Then the high potency of yeast extracts was discovered (Goldberger & Tanner, 1925) and their opinion changed again to pellagra's being aB-vitamin deficiency. Dogs proved useful model animals; a pellagrous human diet induced a disease-condition,blacktongue, with some striking similarities to pellagra (Goldberger & Wheeler, 1928). They had, in fact, provided Goldberger with the first evidence of the potency of yeast extracts (Goldberger et al, 1918a).…”