Experimental autoimmune uveitis and other animal models of uveitis: An update

Bansal, Svati; Barathi, Veluchamy A; Iwata, Daiju; Agrawal, Rupesh

doi:10.4103/0301-4738.156914

Cited by 48 publications

(26 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Experimental autoimmune uveitis (EAU) is the most widely studied disease model for human non-infectious uveitis (24). In EAU, immune responses targeting the neural retina and related tissue are mainly induced by T cells (25,26). Both active immunization of retinal antigens and adoptive transfer of autoreactive T cells can induce EAU in genetically susceptible animals (27).…”

Section: Experimental Models For Non-infectious Uveitismentioning

confidence: 99%

See 1 more Smart Citation

A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis

Zhu

Chen

2021

Front. Immunol.

View full text Add to dashboard Cite

Non-infectious uveitis is an inflammatory disorder of the eye that accounts for severe visual loss without evident infectious agents. While T cells are supposed to dominate the induction of inflammation in non-infectious uveitis, the role of B cells in the pathogenesis of this disease is obscure. Therefore, this review aimed to discuss diverse B-cell participation in different non-infectious uveitides and their roles in the pathogenesis of this disease as well as the mechanism of action of rituximab. Increasing evidence from experimental models and human non-infectious uveitis has suggested the participation of B cells in non-infectious uveitis. The participation levels vary in different uveitides. Furthermore, B cells play multiple roles in the pathogenic mechanisms. B cells produce autoantibodies, regulate T cell responses via antibody-independent functions, and constitute ectopic lymphoid structures. Regulatory B cells perform pivotal anti-inflammatory functions in non-infectious uveitis. Rituximab may work by depleting pro-inflammatory B cells and restoring the quantity and function of regulatory B cells in this disease. Identifying the levels of B-cell participation and the associated roles is beneficial for optimizing therapy. Diversified experimental model choices and emerging tools and/or methods are conducive for future studies on this topic.

show abstract

Section: Experimental Models For Non-infectious Uveitismentioning

confidence: 99%

“…Of these, mice and rats are the most widely used animals (28). Experimental models recapitulating different uveitides are pivotal for exploring the pathogenic mechanisms of the disease (26). However, no single animal model represents the complete spectrum of human non-infectious uveitis (26).…”

Section: Experimental Models For Non-infectious Uveitismentioning

confidence: 99%

A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis

Zhu

Chen

2021

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…При цьому використовували метод ферментативно-посиленої хемілюмінісценції, яка забезпечує високу точність показників та швидкість отримання результатів. В роботі аналізатора «Іmmulite» були використані ліцензійні реактиви виробника приладу (Lin, Suhler, & Rosenbaum, 2014;Duica, Voinea, Mitulescu, Istrate, Coman, & Ciuluvica, 2018;Chen, Qian, Horai, Chan, Falick, & Caspi, 2013;Mathews, Mathews, & Jones, 2010;Bansal, Barathi, Iwata, & Agrawal, 2015;Khalili, 2018;Waters, Terrell, & Jones, 1986).…”

Section: матеріал і методи дослідженьunclassified

Modelling and treatment of the uveitis in rabbit

Doroshchuk¹

2019

VTTP

View full text Add to dashboard Cite

Modelling of the toxico-allergic uveitis is better conducted on rabbits. For the treatment, contrary to corticosteroids that generate a number of side effects (e.g. suppression of reaction, immune inhibitions etc.), one can successfully use nonsteroid drugs, particularly Voltaren and Vetofluxin, which render phagocytes stimulation and immunoglobulin control. As a result, use of these drugs brings to recovery within 7 days. The decrease in the level of immunoglobulins in the blood serum during the treatment of uveitis compared with levels untreated animals was accompanied by a sharp attenuation of the inflammatory response in the blood test and taking into account the features of immunological protection of the eye (the presence of blood-ocular barrier between blood and chamber moisture, vascular membrane, retina, vitreous body) it should be emphasized that the body as a whole responds to the inflammatory process in the uveal tract. Considering toxico-allergic uveitis as an autoimmune disease and in respect that the positive effects of the drugs used on inflammatory and allergic processes, we can predict that the drugs we use are able to participate in the regulation of antibody-forming function of Bcells and inhibite autoimmune disorders. Both treatment schemes show the stimulating effect on phagocytosis, comparing with using phytohemagglutinin, which show no effect. In experimental toxico-allergic uveitis, the treatment regimen in the first experimental group not only did not reduce, but moreover, retained the potential effect on the phagocytic activity of leukocytes. Compared with phytohemagglutinin impact on phagocytosis, found that both represented treatment strategies stimulate the phagocytosis. In experimental toxico-allergic uveitis, Voltaren and Vetofluxin not only did not reduce, as is usually the case with corticosteroids, but moreover, clearly showed a stimulating effect on the phagocytic activity of peritoneal macrophages. Thus, studies have shown that in the treatment of such a severe inflammatory process as uveitis, in contrast to corticosteroids, the use of which is accompanied by a number of undesirable effects (inhibition of regeneration, inhibition of immune reactions, etc.), you can successfully use non-steroidal anti-inflammatory drugs, in particular Voltaren and Vetofluxin. The stimulating phagocytosis effect of Voltaren and Vetofluxin and ability to regulate the levels of immunoglobulins during inflammation has been established.

show abstract

“… 77 , 78 Etiology-specific mouse models for cytomegalovirus (CMV) retinitis and tubercular uveitis also have been developed, highlighting the heterogeneity of immune stimulation seen in human uveitis patients. 79 – 81 …”

Section: Proteomics For the Diagnosis Of Idiopathic Uveitismentioning

confidence: 99%

Personalized Proteomics for Precision Health: Identifying Biomarkers of Vitreoretinal Disease

Vélez

Tang

Cabral

et al. 2018

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Proteomic analysis is an attractive and powerful tool for characterizing the molecular profiles of diseased tissues, such as the vitreous. The complexity of data available for analysis ranges from single (e.g., enzyme-linked immunosorbent assay [ELISA]) to thousands (e.g., mass spectrometry) of proteins, and unlike genomic analysis, which is limited to denoting risk, proteomic methods take snapshots of a diseased vitreous to evaluate ongoing molecular processes in real time. The proteome of diseased ocular tissues was recently characterized, uncovering numerous biomarkers for vitreoretinal diseases and identifying protein targets for approved drugs, allowing for drug repositioning. These biomarkers merit more attention regarding their therapeutic potential and prospective validation, as well as their value as reproducible, sensitive, and specific diagnostic markersTranslational RelevancePersonalized proteomics offers many advantages over alternative precision-health platforms for the diagnosis and treatment of vitreoretinal diseases, including identification of molecular constituents in the diseased tissue that can be targeted by available drugs.

show abstract

Experimental autoimmune uveitis and other animal models of uveitis: An update

Cited by 48 publications

References 45 publications

A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis

A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis

Modelling and treatment of the uveitis in rabbit

Personalized Proteomics for Precision Health: Identifying Biomarkers of Vitreoretinal Disease

Contact Info

Product

Resources

About