Experimental Autoimmune Myocarditis: Role of Renin Angiotensin System

Watanabe, Kenichi; Arumugam, Somasundaram; Thandavarayan, Rajarajan Amirthalingam; Kodama, Makoto

doi:10.5772/20217

Cited by 1 publication

(1 citation statement)

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“…As widely described in literature [7], the complex renin-angiotensin system (RAS) plays a crucial role in the pathophysiology of several morbidities, such as hypertension, diabetes mellitus, myocarditis [8], heart failure and myocardial infarction, where the use of RAS blockers is essential for management. ACE inhibitors (ACEIs) and/or angiotensin II receptor blockers (ARBs) delay or prevent the onset of heart failure in asymptomatic patients with left ventricular systolic dysfunction and, importantly, reduce both mortality and morbidity of patients with heart failure and reduced ejection fraction.…”

Section: Renin-angiotensin-aldosterone System Blockade In Cardiovascu...mentioning

confidence: 99%

COVID‐19 and renin‐angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) ‐ Is there any scientific evidence for controversy?

et al. 2020

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Renin–angiotensin system (RAS) blockers are extensively used worldwide to treat many cardiovascular disorders, where they are effective in reducing both mortality and morbidity. These drugs are known to induce an increased expression of angiotensin‐converting enzyme 2 (ACE2). ACE2 acts as receptor for the novel SARS coronavirus‐2 (SARS‐CoV‐2) which raising the important issue of possible detrimental effects that RAS blockers could exert on the natural history and pathogenesis of the coronavirus disease‐19 (COVID‐19) and associated excessive inflammation, myocarditis and cardiac arrhythmias. We review the current knowledge on the interaction between SARS‐CoV‐2 infection and RAS blockers and suggest a scientific rationale for continuing RAS blockers therapy in patients with COVID‐19 infection.

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Section: Renin-angiotensin-aldosterone System Blockade In Cardiovascu...mentioning

confidence: 99%