Experimental autoimmune encephalomyelitis accelerates remyelination after lysophosphatidylcholine-induced demyelination in the corpus callosum

Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model

“…LPC mainly leads to the cleavage of myelin membrane and the integrity of axon. As the immune response of demyelination induced by LPC is mild, most axons are not damaged [15,22]. In this study, the demyelination lesion, caused by a stereoscopic injection of LPC, was manifested by partial myelin loss within the corpus callosum.…”

Brief electrical nerve stimulation enhances intrinsic repair capacity of the focally demyelinated central nervous system

“…While no single preclinical animal model of MS recapitulates all the aspects of MS pathogenesis, the LPC model has emerged as a strong model in which to study demyelination and remyelination events. This is primarily because the region that is demyelinated can be precisely induced, in contrast to the more widely studied experimental autoimmune encephalomyelitis model of focal demyelination where the precise location of the lesions is not predictable (Lassmann and Bradl, 2017;Lamport et al, 2019). While LPC does effect a precise and robust focal demyelination in the injected area, a further challenge was ensuring that the LPC-demyelinated regions of dorsal columns contained sensory afferents from the sciatic nerve that was stimulated 7 days post LPC injection.…”