Experimental assessment of a new research tool for the estimation of two-dimensional myocardial strain

Langeland, Stian; Wouters, Patrick; Claus, Piet; Leather, H. Alex; Bijnens, Bart; Sutherland, George R.; Rademakers, Frank; D’hooge, Jan

doi:10.1016/j.ultrasmedbio.2006.06.021

Cited by 77 publications

(46 citation statements)

References 14 publications

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“…This shows that the current 3DSE approach cannot accurately define the radial strain component. In fact, radial strain estimation with the 2DST still remains challenging and is not accurate either [29]. Most likely, this is related to the fact that the spatial motion gradient has to be calculated over a relatively small region due to the limited wall thickness in combination with limited spatial resolution of the image.…”

Section: Discussionmentioning

confidence: 99%

Comparison of a new methodology for the assessment of 3D myocardial strain from volumetric ultrasound with 2D speckle tracking

Jasaitytė

Heyde

Ferferieva

et al. 2011

Int J Cardiovasc Imaging

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An alternative approach to extract 3D myocardial strain based on elastic registration of the ultrasound images (3DSE) was developed by our lab. The aim of the present study was to test its clinical performance by comparing strain values obtained by 3DSE with the ones obtained with 2D speckle tracking (2DST). Standard 2D B-mode and volumetric datasets were acquired in 12 patients with coronary heart disease (CHD) and in 12 control subjects. Longitudinal (ε(LL)), circumferential (ε(CC)) and radial (ε(RR)) strain values were obtained from 2D datasets using commercially available 2DST software and from volumetric datasets using the 3DSE approach. 3DSE provided lower strain values than 2DST. With both approaches global ε(LL) and ε(CC) were significantly lower in patients with CHD than in controls. Global ε(LL) and ε(CC) correlated well between both methods (R = 0.83, R = 0.86, respectively), while segmental correlations were moderate [R = 0.63 (ε(LL)), R = 0.41 (ε(CC))]. The highest differences in ε(LL) values obtained by the two methods and the highest number of erroneous ε(LL) with 3DSE were observed in the basal LV segments. This study shows that in real-life datasets our 3DSE method provides global and regional ε(LL) and ε(CC) values that are comparable with the ones obtained from 2DST, even though they are not interchangeable with each other. As only a single acquisition is required, 3D methods may offer advantages over the current 2D techniques. However, the accuracy of the 3DSE can still be improved by solving the problems that appear with deformation estimation in the basal segments.

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Section: Discussionmentioning

confidence: 99%

Comparison of a new methodology for the assessment of 3D myocardial strain from volumetric ultrasound with 2D speckle tracking

Jasaitytė

Heyde

Ferferieva

et al. 2011

Int J Cardiovasc Imaging

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“…Radial strain, an in vivo approximation of contractile function that is angle of insonation independent, 38 was derived from 2-dimensional speckle-tracking analysis of parasternal short-axis images at the level of the papillary muscle according to standard guidelines, 39 using commercially available software (Echopac PC; GE Medical Systems, Milwaukee, WI). Radial strain was normalized to percentage of cardiac cycle using linear interpolation to account for between-group differences in heart rate.…”

Section: In Vivo Echocardiography Rodentmentioning

confidence: 99%

Cardiac Consequences of Autonomic Dysreflexia in Spinal Cord Injury

et al. 2016

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Abstract-Autonomic dysreflexia (AD), which describes episodic hypertension, is highly prevalent in people with spinal cord injury (SCI). In non-SCI, primary hypertension depresses cardiac contractile reserve via β-adrenergic mechanisms.In this study, we investigated whether AD contributes to the impairment in cardiac contractile function that accompanies SCI. We induced SCI in rodents and stratified them into sham, SCI, or SCI plus repetitive induction of AD. At 6-week post-SCI, we assessed cardiac function using in vivo (speckle-tracking echocardiography), ex vivo (working heart), and molecular approaches (Western blot). We also provide unique translational insight by comparing the relationship between the number of daily AD events and cardiac function in 14 individuals with cervical SCI. We found SCI and SCI plus repetitive induction of AD exhibited a reduction in left ventricular dimensions at 6-week post-SCI versus preinjury (P<0.049). Compared with sham, SCI exhibited a reduction in peak radial strain along with a down and rightward shift in the Starling curve (P<0.037), both of which were further depressed in SCI plus repetitive induction of AD (P<0.042). In response to β-adrenergic stimulation, SCI plus repetitive induction of AD exhibited an attenuated increase in contractile indices (P<0.001), despite no differences in β-receptor expression within the left ventricle. Our clinical data confirm our experimental findings by demonstrating significant associations between the number of daily AD events and markers of systolic and diastolic function along with left ventricular mechanics. Here, we provide the first evidence from a translational perspective that AD exerts insidious effects on cardiac function in rodents and humans with SCI.

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“…At faster heart rates and lower frame rates, or during translational motion, speckles may move outside of the region searched by the tracking algorithm. Tracking speckle movement perpendicular to the ultrasound beam may be less accurate than tracking movement parallel to the beam [ 24 ]. Speckle tracking requires specialized software and offl ine analysis to obtain a full characterization of myocardial motion.…”

Section: Speckle Tracking: Multidirectional Measurementsmentioning

confidence: 99%

Insights into myocardial mechanics in normal and pathologic states using newer echocardiographic techniques

Kirkpatrick

Lang²

2008

Curr Heart Fail Rep

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Assessment of myocardial mechanics has been an important research endeavor in echocardiography for many years. Advances in understanding cardiac motion, coupled with treatments that address derangements in myocardial mechanics, have suggested that clinical application of this research may benefit patients in the detection of subclinical disease, quantification of myocardial tissue dynamics, and tracking changes in disease progression or in response to therapies. Newer techniques developed over the past two decades may better address the complex mechanics of cardiac motion than standard anatomic and physiologic echocardiographic measurements. This review describes the mechanics underlying the complexities of myocardial motion and describes standard and novel ways to measure these mechanics, including three-dimensional echocardiography, tissue Doppler imaging, and speckle tracking. Current and future applications of these methods are discussed, along with limitations.

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Experimental assessment of a new research tool for the estimation of two-dimensional myocardial strain

Cited by 77 publications

References 14 publications

Comparison of a new methodology for the assessment of 3D myocardial strain from volumetric ultrasound with 2D speckle tracking

Comparison of a new methodology for the assessment of 3D myocardial strain from volumetric ultrasound with 2D speckle tracking

Cardiac Consequences of Autonomic Dysreflexia in Spinal Cord Injury

Insights into myocardial mechanics in normal and pathologic states using newer echocardiographic techniques

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