Experimental anti-ulcer activity of veronica officinalis L. extracts

The plant kingdom as a source of anti-ulcer remedies

“…The protective effect of FM 100 fraction has been confirmed by clinical observation (Takagi et al, 1969). Saitoh et al (1976) isolated new isoflavonoids and chalcones from the fraction FM 100, which could Scarlat et al, 1985 contribute to the anti-ulcer activity of liquorice. Simple derivatives of glycyrrhetinic acid (the genin of glycyrrhizinic acid) such as carbenoxolone (an ester derivative) and deglycyrrhizinized liquorice (DGL), have been used extensively in gastric ulcer treatment (Habib et al, 1979;Bennett et al, 1980).…”

“…Tannins are known to 'tan' the outermost layer of the mucosa and to render it less permeable and more resistant to chemical and mechanical injury or irritation (Asuzu and Onu, 1990); however, the correlation between the molecular Scarlat et al, 1985 structures of tannins and the astringent/anti-ulcer activity is not known. When a low concentration of tannins is applied to the mucosa, only the outermost layer is tanned, becoming less permeable and affording an increased protection to the subjacent layers against the action of bacteria, chemical irritation, and, to a certain extent, against mechanical irritation.…”

Traditionally used Veronica officinalis inhibits proinflammatory mediators via the NF-κB signalling pathway in a human lung cell line

“…In Europe, Veronica officinalis L. is a widespread species found growing along forest edges, in underwood and meadows up to subalpine altitudes (Flora, 1960;Scarlat et al, 1985). Especially in the 16th and 17th centuries Veronica officinalis was recommended for stomach and intestinal diseases, renal lithiasis, colic and pulmonary diseases.…”

“…Especially in the 16th and 17th centuries Veronica officinalis was recommended for stomach and intestinal diseases, renal lithiasis, colic and pulmonary diseases. In Romanian folk medicine, it was used for kidney diseases, cough, and catarrh, and was known for its wound healing properties and its indication in lung diseases (Madaus, 1938;Scarlat et al, 1985). To explain the effects of the Common Speedwell in the treatment of inflammatory lung diseases, we performed in vitro experiments using the human lung epithelial cell line A549 to analyze the proteins and signaling molecules that are involved in inflammatory processes.…”

Anti-ulcer activity of Synadenium grantii latex

“…Also, this latex may contain chemical substances that can act to promote antiulcerogenic action ( Figure 5). Our preliminary phytochemical results indicated the presence of secondary metabolites (phenolic compounds/unsaponificable substances) in S. grantii that suggest that the antiulcerogenic effect of the latex in relation to the indomethacin and ethanol models, may be related to the presence of those substances in the appraised material (Alcaraz & Hoult, 1985;Aguwa, 1985;Bronner & Landry, 1985;Scarlat et al, 1985;Aguwa & Okunji, 1986;Beil et al, 1995;Matsuda et al, 1998;Araújo et al, 2002). However, it should be noted that the pure latex presented high values of CL50 when evaluated using the sharp toxicity with A. saline experiment and it presented biochemical alterations in relation to the ALT and AST parameters.…”