Experimental and theoretical insights of functionalized hexavanadates on Na+/K+-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays

Bošnjaković-Pavlović, Nada; Xu, Xinyu; Krstić, Danijela; Gillet, Jean‐Michel; Wei, Yongge; Wu, Pingfan; Čolović, Mirjana B.; Biré, Anne Spasojević-de

doi:10.1016/j.jinorgbio.2019.110720

Cited by 7 publications

(4 citation statements)

References 67 publications

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“…23,61,[63][64][65][66][67] Furthermore, this post-functionalization strategy can be extended to functionalization with other organic moieties or even other inorganic clusters, resulting in novel hybrid metal-oxo clusters for potential use in catalysis, medicine and molecular magnetism. 8,10,23,[68][69][70] Hence, through the successful synthesis of V 6 -Cl as a novel, accessible, and versatile starting point for the formation of various hybrid structures the range of potential applications of polyoxovanadates can be expanded.…”

Section: Discussionmentioning

confidence: 99%

Rational synthesis of elusive organic–inorganic hybrid metal-oxo clusters: formation and post-functionalization of hexavanadates

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Rational synthesis of elusive organic–inorganic hybrid metal-oxo clusters: formation and post-functionalization of hexavanadates

et al. 2023

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“…23,54,[56][57][58][59][60] Furthermore, this postfunctionalization strategy can be extended to functionalization with other organic moieties, resulting in novel hybrid metaloxo clusters for potential use in catalysis, medicine and molecular magnetism. 8,10,23,61,62 Hence, through the successful synthesis of V6-Cl as a novel, accessible, and versatile starting point for the formation of various hybrid structures the range of potential applications of polyoxovanadates can be expanded.…”

Section: Discussionmentioning

confidence: 99%

Rational Synthesis of Elusive Organic-Inorganic Hybrid Metal-oxo Clusters: Formation and Post-functionalization of Hexavanadates

Marcano

Kalandia

Hecke

et al. 2023

Preprint

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Paving the way towards new functional materials relies increasingly on the challenging task of forming organic-inorganic hybrid compounds. In that regard, discrete atomically-precise metal-oxo nanoclusters have received increasing attention due to the wide range of organic moieties that can be attached onto them through functionalization reactions. The Lindqvist hexavanadate family of clusters ([V6O13{(OCH2)3C-R}2]2-; V6-R) is particularly interesting due to its magnetic, redox, and catalytic properties. However, compared to other metal-oxo cluster types it has been less extensively explored, which is mainly due to poorly understood synthetic challenges and the limited number of viable post-functionalization strategies. In this work, we present an in-depth investigation of the factors that influence the formation of hybrid hexavanadates (V6-R HPOMs) and leverage this knowledge to develop [V6O13{(OCH2)3CNHCOCH2Cl}2]2- (V6-Cl) as a new and tunable platform for the facile formation of discrete hybrid structures based on metal-oxo clusters in high yields. Moreover, we showcase the versatility of the V6-Cl platform through its facile post-functionalization via nucleophilic substitution with various carboxylic acids of differing complexity and with functionalities that are relevant in multiple disciplines of chemistry, such as supramolecular chemistry and biochemistry. Hence, V6-Cl was shown to be a straightforward and versatile starting point for the formation of functional supramolecular structures or other hybrid materials, thereby enabling their exploration in various fields.

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“…(ii) The hexavanadate structure can be chemically fine-tuned without change to the Lindqvist-type metal–oxo skeleton, for example, by heteroatoms , or organic − or organometallic ligands. This allows optimal tailoring for a specific operational field, for example, biochemistry and biomedicine…”

Section: Electronic Modification Of Poms On Surfacesmentioning

confidence: 99%

Insights from Adsorption and Electron Modification Studies of Polyoxometalates on Surfaces for Molecular Memory Applications

et al. 2021

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Metrics & More Article RecommendationsCONSPECTUS: This Account highlights recent experimental and theoretical work focusing on the development of polyoxometalates (POMs) as possible active switching units in what may be called "molecule-based memory cells". Herein, we critically discuss how multiply charged vanadium-containing POMs, which exhibit stable metal−oxo bonds and are characterized by the excellent ability to change their redox states without significant structural distortions of the central polyoxoanion core, can be immobilized best and how they may work optimally at appropriate surfaces. Furthermore, we critically discuss important issues and challenges on the long way toward POM-based nanoelectronics. This Account is divided into four sections shedding light on POM interplay in solution and on surfaces, ion soft-landing of mass-selected POMs on surfaces, electronic modification of POMs on surfaces, and computational modeling of POMs on surfaces. The sections showcase the complex nature of far-reaching POM interactions with the chemical surroundings in solution and the properties of POMs in the macroscopic environment of electrode surfaces. Section 2 describes complex relationships of POMs with their counter-cations, solvent molecules, and water impurities, which have been shown to exhibit a direct impact on the resulting surface morphology, where a concentration-dependent formation of micellar structures can be potentially observed. Section 3 gives insights into the ion softlanding deposition of mass-selected POMs on electrode surfaces, which emerges as an appealing method because the simultaneous deposition of agglomeration-stimulating counter-cations can be avoided. Section 4 provides details of electronic properties of POMs and their modification by external electronic stimuli toward the development of multiple-state resistive (memristive) switches. Section 5 sheds light on issues of the determination of the electronic structure properties of POMs across their interfaces, which is difficult to address by experiment. The studies summarized in these four sections have employed various X-ray-scattering, microscopy, spectroscopy, and computational techniques for imaging of POM interfaces in solution and on surfaces to determine the adsorption type, agglomeration tendency, distribution, and oxidation state of deposited molecules. The presented research findings and conceptual ideas may assist experimentalists and theoreticians to advance the exploration of POM electrical conductivity as a function of metal redox and spin states and to pave the way for a realization of ("brain-inspired") POM-based memory devices, memristive POM-surface device engineering, and energy efficient nonvolatile data storage and processing technologies.

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Experimental and theoretical insights of functionalized hexavanadates on Na+/K+-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays

Cited by 7 publications

References 67 publications

Rational synthesis of elusive organic–inorganic hybrid metal-oxo clusters: formation and post-functionalization of hexavanadates

Rational synthesis of elusive organic–inorganic hybrid metal-oxo clusters: formation and post-functionalization of hexavanadates

Rational Synthesis of Elusive Organic-Inorganic Hybrid Metal-oxo Clusters: Formation and Post-functionalization of Hexavanadates

Insights from Adsorption and Electron Modification Studies of Polyoxometalates on Surfaces for Molecular Memory Applications

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