Experimental and ONIOM computational evaluation of DNA- and BSA-binding and cytotoxic activity of a mononuclear Pd(II) complex with piroxicam

Hadadzadeh, Hassan; Farrokhpour, Hossein; Jannesari, Zahra; Amirghofran, Zahra

doi:10.1016/j.ica.2016.08.051

Cited by 16 publications

(5 citation statements)

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“…The obtained results confirm the cytotoxic and chemo preventive properties of NSAIDs and their metal complexes as reported (Arora et al, 2023a;Devi et al, 2020;Goldman, 1998;Sheng et al, 1997). Interestingly, some of our synthesized complexes exhibited enhanced IC 50 values compared to previously reported piroxicam metal complexes such as Pd and Ni complexes (Christofis et al, 2005;Hadadzadeh et al, 2016).…”

Section: Evaluation Of Antiproliferative Activitysupporting

confidence: 91%

“…The preparation and repurposing of several metal complexes of piroxicam had been reported in some published literatures (Kovala‐Demertzi, 2000; Tamasi et al, 2014). Therefore, in this manuscript, we introduce synthesis of piroxicam Ni (II), Pt (IV), Pd (II), and Ag (I) complexes as shown in Scheme 1, where Ni and Pd complexes were previously reported (Gehad & Nadia, 2004; Hadadzadeh et al, 2016). Metal complexes characterization was done by elemental analysis, different spectroscopic techniques (NMR, IR, UV‐Vis, and mass analyses), molar conductivity and thermogravimetric analysis.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents

Soliman,

El‐sagheir,

Thabet

et al. 2024

Drug Development Research

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Four piroxicam metal complexes; NiL2, PtL2, PdL2, and AgL were synthesized and characterized by different techniques with enhanced antibacterial and anticancer activity. Regarding in vitro antimicrobial activity, complex NiL2 displayed potent antibacterial effect against Escherichia coli and Pseudomonas aeruginosa that was 1.9‐folds higher than piroxicam (minimum inhibitory concentration [MIC] = 31.85, 65.32 µM), respectively. In case of G+ve bacteria, complex PtL2 had potent activity on Staphylococcus aureus which was 2.1‐folds higher than piroxicam (MIC = 43.12 µM), while activity of complex AgL against Enterococcus faecalis was threefolds higher than piroxicam (MIC = 74.57 µM. Complexes PtL2 and PdL2 exhibited higher inhibition of DNA gyrase than piroxicam (IC50 = 6.21 µM) in the range of 1.9–1.7‐folds. The in vitro antiproliferative activity depicted that all investigated complexes showed better cytotoxic effect than piroxicam, specifically Pt and Pd complexes which had lower IC50 values than piroxicam on human liver cancer cell line HepG2 by 1.8 and 1.7‐folds, respectively. While Pd and Ag complexes showed 2 and 1.6‐folds better effect on human colon cancer cell line HT‐29 compared with piroxicam. Molecular modeling studies including docking on Stranded DNA Duplex (1juu) and DNA gyrase enzyme (1kzn) that gave good insight about interaction of complexes with target molecules, calculation of electrostatic potential map and global reactivity descriptors were performed.

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Section: Evaluation Of Antiproliferative Activitysupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents

Soliman,

El‐sagheir,

Thabet

et al. 2024

Drug Development Research

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“…The MDCs of naproxen with lanthanum(III) also shows anti-inflammatory potential [132]. Many more NSAID-MDCs for example piroxicam complex with Zn(II), Ru(II), Ru(III), Cu(II), Co(II), Pd(II), tenoxicam complexes with Ru(III), Cu(II), meloxicam complexes with Ru(II), Cu(II), and Ni(II) have been developed and have been found to possess anti-inflammatory potentials (Figure 5) [133][134][135][136][137][138][139][140]. These complexes can be utilized for treatment of ACI in RA as compared to NSAIDs or NSAIDs with minerals owing to their greater penetrating power into the target cells and hence effective cell-drug interactions, more clinical studies are required for establishment of proper treatment [Table 2].…”

Section: Nsaid-mdcsmentioning

confidence: 99%

Calcium Complexes of Oxicams: New Dimensions in Rheumatoid Arthritis Treatment

et al. 2022

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Various metals have been complexed with drugs to improve their cellular impact. Inflammatory diseases like rheumatoid arthritis (RA) are characterized by unbalanced production of proinflammatory cytokines (PICs) and prostaglandins with decreased levels of vitamin D and calcium. The inflammation can be suppressed through targeting the formation of PICs or related enzymes by various treatment strategies that involve the use of corticosteroids, disease-modifying antirheumatic drugs and NSAIDs. We present a detailed review on the impact of calcium complexes of oxicams as an advanced treatment strategy for RA. The calcium complexes demonstrate promising capabilities to cure the disease, improve the strength of bones and suppress PICs in RA.

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“…[ 9 ] It strongly chelates the divalent metal ions through the oxygen and nitrogen atoms of amide group (O amide ) and thiazolyl ring (N thiazolyl ), respectively. [ 10,11 ]…”

Section: Introductionmentioning

confidence: 99%

“…[9] It strongly chelates the divalent metal ions through the oxygen and nitrogen atoms of amide group (O amide ) and thiazolyl ring (N thiazolyl ), respectively. [10,11] It showed significant anti-inflammatory potential [12] and also exhibited antiradical power as it reduced the reactive oxidants and singlet oxygen production. [13] During inflammation, various types of reactive oxidants are generated and cause oxidative damage which can be prevented by NSAIDs, as these drugs interacted with the oxidative species.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes

Samra

Basra

2023

Applied Organom Chemis

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In the present study, two new meloxicam complexes with Mg(II) and Sr(II) were synthesized and characterized by spectroscopic and analytical methods, that is, UV–vis, IR, 1H NMR, 13C NMR, powder XRD, SEM–EDX, and TG analysis. The biological evaluation was done by in vitro antioxidant, BSA‐binding, DNA cleavage activities, and in vivo anti‐inflammatory, analgesic, and anxiolytic methods. Furthermore, in silico docking was done with Keap1 receptor to visualize the anti‐inflammatory effect of complexes. The spectral characterization suggested that meloxicam coordinated with the metal ions by oxygen and nitrogen of amide group and thiazolyl ring (Oamide and Nthiazolyl), respectively. The SEM pictures depicted dissimilar morphologies, and the powder XRD patterns showed different crystallinities of complexes than meloxicam. TG analysis exhibited high thermal stabilities of complexes and Coats–Redfern method was employed to calculate the important thermodynamic parameters. The complexes showed effective biological activities and enhanced safety index (LD50 = 1000 mg kg−1). The Mg(II) complex revealed greatest inhibitory effects in carrageenan‐induced paw inflammation (92.85%) and in acetic acid‐induced writhing (71.05%). Furthermore, the complexes showed higher potential to bind with BSA and cleave the DNA as compared with the meloxicam. Moreover, molecular docking against Keap1 showed that Mg(II) complex inhibited Keap1 with highest docking score (6166 kcal mol−1), docking area (804.40) and ACE (−417.49 kJ mol−1) which explained its higher anti‐inflammatory effect. Mg(II) complex of meloxicam might be considered as a candidate anti‐inflammatory drug; however, more research is required to investigate their other biological potential.

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Experimental and ONIOM computational evaluation of DNA- and BSA-binding and cytotoxic activity of a mononuclear Pd(II) complex with piroxicam

Cited by 16 publications

References 60 publications

Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents

Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents

Calcium Complexes of Oxicams: New Dimensions in Rheumatoid Arthritis Treatment

Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes

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