Experimental and numerical investigation of orbital atherectomy: absence of cavitation

Ramazani-Rend, Reza; Chelikani, Srikar; Sparrow, E. M.; Abraham, John

doi:10.4236/jbise.2010.311144

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…12,13,17,26,34,36,42,53,54,57,62,[66][67][68][69][70][71][72][73][74]80 Here, the impact of removing or displacing plaque is studied from a hemodynamic perspective. The plaque removal technique employed is orbital atherectomy plus balloon angioplasty or stenting; it is described in the literature, and interested readers are invited to references 10,25,55,62 for details on the procedure.…”

Section: Introductionmentioning

confidence: 99%

Alterations of Blood Flow Through Arteries Following Atherectomy and the Impact on Pressure Variation and Velocity

Plourde

Vallez

Sun

et al. 2016

Cardiovasc Eng Tech

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Simulations were made of the pressure and velocity fields throughout an artery before and after removal of plaque using orbital atherectomy plus adjunctive balloon angioplasty or stenting. The calculations were carried out with an unsteady computational fluid dynamic solver that allows the fluid to naturally transition to turbulence. The results of the atherectomy procedure leads to an increased flow through the stenotic zone with a coincident decrease in pressure drop across the stenosis. The measured effect of atherectomy and adjunctive treatment showed decrease the systolic pressure drop by a factor of 2.3. Waveforms obtained from a measurements were input into a numerical simulation of blood flow through geometry obtained from medical imaging. From the numerical simulations, a detailed investigation of the sources of pressure loss was obtained. It is found that the major sources of pressure drop are related to the acceleration of blood through heavily occluded cross sections and the imperfect flow recovery downstream. This finding suggests that targeting only the most occluded parts of a stenosis would benefit the hemodynamics. The calculated change in systolic pressure drop through the lesion was a factor of 2.4, in excellent agreement with the measured improvement. The systolic and cardiac-cycle-average pressure results were compared with measurements made in a multi-patient study treated with orbital atherectomy and adjunctive treatment. The agreements between the measured and calculated systolic pressure drop before and after the treatment were within 3%. This excellent agreement adds further confidence to the results. This research demonstrates the use of orbital atherectomy to facilitate balloon expansion to restore blood flow and how pressure measurements can be utilized to optimize revascularization of occluded peripheral vessels.

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Section: Introductionmentioning

confidence: 99%

Alterations of Blood Flow Through Arteries Following Atherectomy and the Impact on Pressure Variation and Velocity

Plourde

Vallez

Sun

et al. 2016

Cardiovasc Eng Tech

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“…Abdel-Wahab et al [15] examined the effect of DCP on drug stents. Ramazani-Rend et al [16] assessed the effect of cavitation during the DCP process. Some researchers evaluated the effect of rotational speed during the drilling on restenosis after DCP [4, 17].…”

Section: Introductionmentioning

confidence: 99%

Minimizing thermal damage to vascular nerves while drilling of calcified plaque

Gholampour

Hajirayat

2019

BMC Res Notes

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Objective Drilling of calcified plaque (DCP) inside the artery is a method for removing calcified plaques. This study investigated the effect of drill. To validate the maximum temperature calculated by computer simulation, this value was also measured by an experimental on a phantom model. Results Increasing drill bit diameter during drilling would increase the temperature in vascular nerves. In a drill bit with a diameter of 4 mm, the risk of thermal necrosis in vascular nerves of the artery wall decreased by 8.57% by changing the drill from WC to NT. The same value for a drill bit with a diameter of 6 mm was 10.17%. However, the trend of the generated temperature in the vascular nerves did not change significantly with change of the material and diameter of the drill bit. The results showed that for DCP with the least risk of thermal necrosis in vascular nerves and subsequently the lowest risk of restenosis, coagulation and thermal stroke of the patient, the best option is to use a drill bit with a diameter of 4 mm and NT material for drilling.

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“…Treatment of this type of cardiovascular disease typically fi rst involves dietary and lifestyle changes to reduce the presence of clogging cholesterols within the blood, cholesterol medication, and surgical intervention. Among the most common surgical interventions are balloon angioplasty, stenting, medicated stenting [1][2][3][4][5][6][7], atherectomy [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25], or a combination treatment. One positive outcome of these treatments is that they often increase the compliance of the artery wall which is a measure of cardiovascular health [26][27][28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

A New Catheter Technology to Deliver Vascular Stem-Cells

Plourde¹,

Stark²,

Abraham³

2016

Stud Stem Cells Res Ther

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A new device has been designed, developed and tested to improve the capacity of vascular drug and stem cell delivery. The device consists of a catheter with a multitude of small lumens (instead of a large central channel lumen). The use of multiple lumens provides a number of benefi ts to medical intervention. First, the multiple lumens are spread across the catheter cross section. As a consequence, the medication/stem cells are more effectively dispersed into the artery. Second, the construction of the new catheter has an increased mechanical strength compared to the standard single-lumen cathetertherefore, it is able to resist compressive forces caused by a pressurized balloon. This fact makes the new design able to preserve medication/stem cell fl owrates without causing mechanical hemolysis to the cells. Finally, the newly designed device prohibits clumping of stem cells carried in solution.

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Experimental and numerical investigation of orbital atherectomy: absence of cavitation

Cited by 8 publications

References 23 publications

Alterations of Blood Flow Through Arteries Following Atherectomy and the Impact on Pressure Variation and Velocity

Alterations of Blood Flow Through Arteries Following Atherectomy and the Impact on Pressure Variation and Velocity

Minimizing thermal damage to vascular nerves while drilling of calcified plaque

A New Catheter Technology to Deliver Vascular Stem-Cells

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