Experimental and numerical investigation of polymethyl methacrylate scaffolds for bone tissue engineering

Shirzad, Masoud; Matbouei, Alireza; Fathi, Alireza; Rabiee, Sayed Mahmood

doi:10.1177/1464420720901851

Cited by 8 publications

(8 citation statements)

References 37 publications

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“…Blends (10 wt%, 15 wt% and 20 wt% bioglass) were prepared using a simple melt blending approach, which did not require the use of hazardous solvents. Moreover, contrary to previously reported studies that investigated simple rectangular and circular scaffold architectures, this research investigated anatomically designed scaffolds with pore size gradients that mimicked the architecture of bone and thus, aimed to improve the overall mechanical behaviour of the scaffolds and thereby making them suitable for load-bearing applications [ 55 , 56 , 57 ].…”

Section: Introductionmentioning

confidence: 99%

Novel 3D Bioglass Scaffolds for Bone Tissue Regeneration

et al. 2022

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The design of scaffolds with optimal biomechanical properties for load-bearing applications is an important topic of research. Most studies have addressed this problem by focusing on the material composition and not on the coupled effect between the material composition and the scaffold architecture. Polymer–bioglass scaffolds have been investigated due to the excellent bioactivity properties of bioglass, which release ions that activate osteogenesis. However, material preparation methods usually require the use of organic solvents that induce surface modifications on the bioglass particles, compromising the adhesion with the polymeric material thus compromising mechanical properties. In this paper, we used a simple melt blending approach to produce polycaprolactone/bioglass pellets to construct scaffolds with pore size gradient. The results show that the addition of bioglass particles improved the mechanical properties of the scaffolds and, due to the selected architecture, all scaffolds presented mechanical properties in the cortical bone region. Moreover, the addition of bioglass indicated a positive long-term effect on the biological performance of the scaffolds. The pore size gradient also induced a cell spreading gradient.

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Section: Introductionmentioning

confidence: 99%

Novel 3D Bioglass Scaffolds for Bone Tissue Regeneration

et al. 2022

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“…The method is based on a tertiary system: solvent (chloroform)-polymer-"no" solvent (methanol), in the correct volume ratio. To achieve the preparation of HCP structures is necessary to immerse the substrate in the prepared solution and then, spontaneously evaporate it in the air [16,[35][36][37]. The advantage of this method, except for the humid environment and other active substances, is the exact ratio of solvents [8].…”

Section: Introductionmentioning

confidence: 99%

“…One possibility is to use polymeric materials, mainly due to their simplicity, flexibility, and low cost compared to other materials, and to prove their usefulness as extracellular matrix (ECM) replacements [38]. These properties and many others such as low density, environmental friendliness, and good physical and mechanical properties have been found in polymethyl methacrylate (PMMA) and its derivatives [35], which have been approved as bioinert and biocompatible polymers used in biomedical applications [36,37,39]. Nanocomposites based on PMMA exhibit excellent results in a body environment and have a protective role against corrosion and, thus, increase the durability of biomedical implants [40].…”

Section: Introductionmentioning

confidence: 99%

Cytocompatibility of Polymethyl Methacrylate Honeycomb-like Pattern on Perfluorinated Polymer

et al. 2021

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In this study, we present a simple approach for developing a biocompatible polymer scaffold with a honeycomb-like micropattern. We aimed to combine a plasma treatment of fluorinated ethylene propylene (FEP) substrate with an improved phase separation technique. The plasma exposure served for modification of the polymer surface properties, such as roughness, surface chemistry, and wettability. The treated FEP substrate was applied for the growth of a honeycomb-like pattern from a solution of polymethyl methacrylate (PMMA). The properties of the pattern were strongly dependent on the conditions of plasma exposure of the FEP substrate. The physico-chemical properties of the prepared pattern, such as changes in wettability, aging, morphology, and surface chemistry, were determined. Further, we have examined the cellular response of human osteoblasts (U-2 OS) on the modified substrates. The micropattern prepared with a selected combination of surface activation and amount of PMMA for honeycomb construction showed a positive effect on U-2 OS cell adhesion and proliferation. Samples with higher PMMA content (3 and 4 g) formed more periodic hexagonal structures on the surface compared to its lower amount (1 and 2 g), which led to a significant increase in the pattern cytocompatibility compared to pristine or plasma-treated FEP.

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“…1 These structures have a variety of applications in different areas, such as lightweight engineering, 2,3 sound and thermal insulation, [4][5][6] impact absorption, 7 and biomaterials. 8,9 Moreover, investigations showed that the mechanical behavior of these lattice structure significantly depends on the micro-structure. 10,11 As a result, a considerable number of studies are focused on the relation between unit cell and mechanical properties of cellular structures.…”

Section: Introductionmentioning

confidence: 99%

Architected functionally graded porous lattice structures for optimized elastic-plastic behavior

Mahbod

Asgari

Mittelstedt

2020

Proceedings of the Institution of Mechanical Engineers, Part L:

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In this paper, the elastic–plastic mechanical properties of regular and functionally graded additively manufactured porous structures made by a double pyramid dodecahedron unit cell are investigated. The elastic moduli and also energy absorption are evaluated via finite element analysis. Experimental compression tests are performed which demonstrated the accuracy of numerical simulations. Next, single and multi-objective optimizations are performed in order to propose optimized structural designs. Surrogated models are developed for both elastic and plastic mechanical properties. The results show that elastic moduli and the plastic behavior of the lattice structures are considerably affected by the cell geometry and relative density of layers. Consequently, the optimization leads to a significantly better performance of both regular and functionally graded porous structures. The optimization of regular lattice structures leads to great improvement in both elastic and plastic properties. Specific energy absorption, maximum stress, and the elastic moduli in x- and y-directions are improved by 24%, 79%, 56%, and 9%, respectively, compared to the base model. In addition, in the functionally graded optimized models, specific energy absorption and normalized maximum stress are improved by 64% and 56%, respectively, in comparison with the base models.

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Experimental and numerical investigation of polymethyl methacrylate scaffolds for bone tissue engineering

Cited by 8 publications

References 37 publications

Novel 3D Bioglass Scaffolds for Bone Tissue Regeneration

Novel 3D Bioglass Scaffolds for Bone Tissue Regeneration

Cytocompatibility of Polymethyl Methacrylate Honeycomb-like Pattern on Perfluorinated Polymer

Architected functionally graded porous lattice structures for optimized elastic-plastic behavior

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