This article examined the effectiveness of bioclimatic strategies to enhance thermal comfort and decrease energy consumption in a desert-climate residence. The study assessed the impact of thermal insulation, natural ventilation, and phase-change materials (PCMs) over a year, with each strategy evaluated both independently and in combination. Monthly energy bills were analyzed to determine the impact of these strategies. The results indicated substantial reductions in energy costs, with decreases of up to 50% during transitional seasons; however, the complete elimination of heating and cooling systems was not feasible due to significant thermal phase differences between indoor and outdoor environments. Further analysis of thermal discomfort hours revealed that increasing insulation thickness during specific seasons could mitigate peak heat intensity and delay its occurrence, thus extending periods of comfort and reducing discomfort hours. Despite these improvements, some periods of thermal distress persisted during the warmest months, underscoring the necessity for a balanced approach to climate adaptation strategies. Overall, the implementation of these strategies proved effective in improving comfort and reducing energy usage in desert-climate homes, although they do not fully negate the need for traditional heating and cooling systems.