Experimental and numerical analysis of short-pulse laser interaction with tissue phantoms containing inhomogeneities

Das, Champak; Trivedi, Ashish; Mitra, Kunal; Vo‐Dinh, Tuan

doi:10.1364/ao.42.005173

Cited by 29 publications

(15 citation statements)

References 31 publications

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“…India ink is used as the absorber. Details about phantom preparation can be found in the previous papers of the authors [51]. The layered-tissue phantom consists of three-layers having different optical properties representing epidermis, dermis, and fatty tissues of human skin.…”

Section: Experimental Methodsmentioning

confidence: 99%

Bio-heat transfer analysis during short pulse laser irradiation of tissues

Jaunich¹,

Raje²,

Kim³

et al. 2008

International Journal of Heat and Mass Transfer

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216

112

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Section: Experimental Methodsmentioning

confidence: 99%

Bio-heat transfer analysis during short pulse laser irradiation of tissues

Jaunich¹,

Raje²,

Kim³

et al. 2008

International Journal of Heat and Mass Transfer

Self Cite

216

112

View full text Add to dashboard Cite

“…Several studies on the RTE-based forward model have been reported. [96][97][98] Typically, the RTE is solved numerically, with only a few analytical solutions reported. 99,100 One of the most common methods for solving the RTE is the discrete-ordinate method, which is compatible with finite difference, finite volume, or finite element schemes.…”

Section: Hybrid Model Based On the Radiative Transfer Equation And Thmentioning

confidence: 99%

“…99,100 One of the most common methods for solving the RTE is the discrete-ordinate method, which is compatible with finite difference, finite volume, or finite element schemes. 97,101 Even with current advanced computer technology, however, the heavy computational load is still the biggest drawback with the RTE. A variety of fast solvers of the RTE have been proposed, [102][103][104][105] and among these a hybrid model-based the RTE and DE is one of the most promising approaches.…”

Section: Hybrid Model Based On the Radiative Transfer Equation And Thmentioning

confidence: 99%

Overview of diffuse optical tomography and its clinical applications

2016

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Near-infrared diffuse optical tomography (DOT), one of the most sophisticated optical imaging techniques for observations through biological tissue, allows 3-D quantitative imaging of optical properties, which include functional and anatomical information. With DOT, it is expected to be possible to overcome the limitations of conventional near-infrared spectroscopy (NIRS) as well as offering the potential for diagnostic optical imaging. However, DOT has been under development for more than 30 years, and the difficulties in development are attributed to the fact that light is strongly scattered and that diffusive photons are used for the image reconstruction. The DOT algorithm is based on the techniques of inverse problems. The radiative transfer equation accurately describes photon propagation in biological tissue, while, because of its high computation load, the diffusion equation (DE) is often used as the forward model. However, the DE is invalid in low-scattering and/or highly absorbing regions and in the vicinity of light sources. The inverse problem is inherently ill-posed and highly undetermined. Here, we first summarize NIRS and then describe various approaches in the efforts to develop accurate and efficient DOT algorithms and present some examples of clinical applications. Finally, we discuss the future prospects of DOT.

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“…Others, including the present authors, have investigated the application of the radiation transport equation ͑RTE͒. [27][28][29][30][31][32][33][34][35][36][37][38][39][40] Unlike the diffusion approximation, the RTE can accurately predict the propagation of photons through highly absorptive and void-like tissues, and is not limited by practical separation distances between the source and detectors. Furthermore, the directionality of incident light owing to fiber optic delivery and collection of light can be predicted.…”

Section: Introductionmentioning

confidence: 99%

Radiative transport in fluorescence‐enhanced frequency domain photon migration

et al. 2006

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Small animal optical tomography has significant, but potential application for streamlining drug discovery and pre-clinical investigation of drug candidates. However, accurate modeling of photon propagation in small animal volumes is critical to quantitatively obtain accurate tomographic images. Herein we present solutions from a robust fluorescence-enhanced, frequency domain radiative transport equation (RTE) solver with unique attributes that facilitate its deployment within tomographic algorithms. Specifically, the coupled equations describing time-dependent excitation and emission light transport are solved using discrete ordinates (SN) angular differencing along with linear discontinuous finite-element spatial differencing on unstructured tetrahedral grids. Source iteration in conjunction with diffusion synthetic acceleration is used to iteratively solve the resulting system of equations. This RTE solver can accurately and efficiently predict ballistic as well as diffusion limited transport regimes which could simultaneously exist in small animals. Furthermore, the solver provides accurate solutions on unstructured, tetrahedral grids with relatively large element sizes as compared to commonly employed solvers that use step differencing. The predictions of the solver are validated by a series of frequency-domain, phantom measurements with optical properties ranging from diffusion limited to transport limited propagation. Our results demonstrate that the RTE solution consistently matches measurements made under both diffusion and transport-limited conditions. This work demonstrates the use of an appropriate RTE solver for deployment in small animal optical tomography.

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Experimental and numerical analysis of short-pulse laser interaction with tissue phantoms containing inhomogeneities

Cited by 29 publications

References 31 publications

Bio-heat transfer analysis during short pulse laser irradiation of tissues

Bio-heat transfer analysis during short pulse laser irradiation of tissues

Overview of diffuse optical tomography and its clinical applications

Radiative transport in fluorescence‐enhanced frequency domain photon migration

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