Experimental and molecular modeling studies on the interaction of the Ru(II)-piroxicam with DNA and BSA

Jannesari, Zahra; Hadadzadeh, Hassan; Khayamian, Taghi; Maleki, Batool; Rudbari, Hadi Amiri

doi:10.1016/j.ejmech.2013.08.051

Cited by 36 publications

(11 citation statements)

References 61 publications

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“…The changes in the UV−vis spectra of the colloidal solution of Au NP−Pir in comparison with the Pir solution can propose the donation of the lone electron pairs of the O amide and N pyridyl atoms to the Au NPs surface (i.e., a charge transfer from Pir to the Au surface). 55,56 In the visible region, the absorption spectra show the characteristic plasmon band of Au NPs around 520 nm, which is consistent with previous reports (Figure 2). 35 This band does not show any significant change in its original wavelength, which indicates that the agglomeration of Au NPs can be avoided in the Au NP−Pir conjugated colloid.…”

Section: Resultssupporting

confidence: 92%

“…The shoulder band at 286 nm, attributed to the n → π* transition of the CO group of the amide moiety in Pir, is shifted to shorter wavelengths as the Au NPs concentration increases, revealing the involvement of this group in the conjugation process. ,− The band at 352 nm in the free Pir, assigned to the n → π* transition of the pyridyl nitrogen is blue-shifted during the ablation time. The changes in the UV–vis spectra of the colloidal solution of Au NP–Pir in comparison with the Pir solution can propose the donation of the lone electron pairs of the O amide and N pyridyl atoms to the Au NPs surface (i.e., a charge transfer from Pir to the Au surface). , In the visible region, the absorption spectra show the characteristic plasmon band of Au NPs around 520 nm, which is consistent with previous reports (Figure ). This band does not show any significant change in its original wavelength, which indicates that the agglomeration of Au NPs can be avoided in the Au NP–Pir conjugated colloid.…”

Section: Resultsmentioning

confidence: 99%

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Combined Experimental and Computational Study of the In Situ Adsorption of Piroxicam Anions on the Laser-Generated Gold Nanoparticles

et al. 2017

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Gold nanoparticle–piroxicam anion conjugates (Au NP–Pir) were synthesized in a green method using laser ablation of a gold foil in an aqueous solution of anionic piroxicam (NaPir). The produced Au NP–Pir conjugates were characterized by different spectroscopic techniques and transmission electron microscopy. The fluorescence and absorption spectra of Au NP–Pir colloidal solution were recorded at different concentrations of the Au NPs to investigate the effect of conjugation on the spectral properties of both the free Pir anion and Au NPs. Comparing the FT-IR spectrum of the colloidal solution of Au NP–Pir with that of the solution of the free Pir anion indicates that this anion binds to the surface of Au NPs through its different binding sites, viz., the pyridyl nitrogen atom, the SO2 group, and the amide oxygen atom. To support the experimental observations, theoretical calculations were also performed to evaluate the interaction of different binding sites of Pir with one Au atom and the effect of this interaction on the IR spectrum of Pir. In a more realistic theoretical study, the optimized geometry of Pir on the Au(111) surface was calculated, and its orientation toward the surface of Au was obtained. The calculations show that the pyridyl ring of Pir prefers to orient perpendicular to the surface of Au, and the O atoms of the SO2 and amide groups are responsible for the interaction with the surface. The cytotoxic effect of the free Pir anion and Au NP–Pir conjugates against the Jurkat T-cells was studied using an MTT assay. The results show that only the Au NP–Pir conjugates have significant anticancer activity against the Jurkat T-cells with an IC50 value of 33.8 ± 2 μg/mL. In comparison with the pure Au NPs and free Pir, the Au NP–Pir conjugates show a significant antimicrobial activity against two pathogens including Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus).

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Combined Experimental and Computational Study of the In Situ Adsorption of Piroxicam Anions on the Laser-Generated Gold Nanoparticles

et al. 2017

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“…illustrates that this complex has a high quenching efficiency and can effectively compete for the DNA-binding sites with EB[61]. This K SV is greater than the values obtained for many…”

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confidence: 56%

A mononuclear Cu(II) complex with 5,6-diphenyl-3-(2-pyridyl)-1,2,4-triazine: Synthesis, crystal structure, DNA- and BSA-binding, molecular modeling, and anticancer activity against MCF-7, A-549, and HT-29 cell lines

Anjomshoa

Hadadzadeh

Torkzadeh‐Mahani

et al. 2015

European Journal of Medicinal Chemistry

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“…Fluorescence spectral technique is an effective method to study the interaction of organic compounds with DNA[17, 38,42]. The binding mode of DNA with compound 6d was further investigated using fluorescence emission spectroscopy.…”

Section: Fluorescence Emission Spectramentioning

confidence: 99%

Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents

Zhang

Chen

Wang

et al. 2015

European Journal of Medicinal Chemistry

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Experimental and molecular modeling studies on the interaction of the Ru(II)-piroxicam with DNA and BSA

Cited by 36 publications

References 61 publications

Combined Experimental and Computational Study of the In Situ Adsorption of Piroxicam Anions on the Laser-Generated Gold Nanoparticles

Combined Experimental and Computational Study of the In Situ Adsorption of Piroxicam Anions on the Laser-Generated Gold Nanoparticles

A mononuclear Cu(II) complex with 5,6-diphenyl-3-(2-pyridyl)-1,2,4-triazine: Synthesis, crystal structure, DNA- and BSA-binding, molecular modeling, and anticancer activity against MCF-7, A-549, and HT-29 cell lines

Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents

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