Experimental and modeling study of catalytic reaction of glucose isomerization: Kinetics and packed‐bed dynamic modeling

Dehkordi, Asghar Molaei; Safari, Iman; Karima, Muhammad M.

doi:10.1002/aic.11460

Cited by 15 publications

(8 citation statements)

References 25 publications

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“…102 The ability to model biocatalyst performance over time allows the determination of optimal operating conditions and the refinement of cost models for the overall process. 102,103 The kinetic properties of immobilized glucose isomerase have been studied by numerous research groups who have sought to characterize a range of kinetic properties including process productivity and stability, [102][103][104][105][106] thermal inactivation rates, 40,107 the nature and effect of diffusional constraints, [108][109][110] substrate preferences, 34 and the effects of substrate protection on inactivation rates. 77,78 One of the key issues for immobilized enzymes in general relates to limitations in mass transfer relative to soluble forms of the enzyme, the effect of which is to lower the effective specific activity of the biocatalyst.…”

Section: Immobilized Glucose Isomerase Processesmentioning

confidence: 99%

Industrial use of immobilized enzymes

et al. 2013

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Although many methods for enzyme immobilization have been described in patents and publications, relatively few processes employing immobilized enzymes have been successfully commercialized. The cost of most industrial enzymes is often only a minor component in overall process economics, and in these instances, the additional costs associated with enzyme immobilization are often not justified. More commonly the benefit realized from enzyme immobilization relates to the process advantages that an immobilized catalyst offers, for example, enabling continuous production, improved stability and the absence of the biocatalyst in the product stream. The development and attributes of several established and emerging industrial applications for immobilized enzymes, including high-fructose corn syrup production, pectin hydrolysis, debittering of fruit juices, interesterification of food fats and oils, biodiesel production, and carbon dioxide capture are reviewed herein, highlighting factors that define the advantages of enzyme immobilization.

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Section: Immobilized Glucose Isomerase Processesmentioning

confidence: 99%

Industrial use of immobilized enzymes

et al. 2013

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“…1, February 2013 predict the concentration profiles of D-glucose and D-fructose within the reactor. The experimental results indicated that the model prediction of the transient and steady-state performance of the packed-bed reactor was satisfactory and as such could be used in the design of a fixed-bed IGI catalytic reactor [23].…”

Section: Introductionmentioning

confidence: 90%

Kinetics of a Three-Step Isomerization of Glucose to Fructose Using Immobilized Enzyme

Gaily¹,

Sulieman²,

Abasaeed³

2013

IJCEA

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Abstract-A three-step complex formation of fructose by glucose isomerization was suggested to describe the isomerization kinetics. The model was characterized by the formation of a fructose complex. Experimental data obtained from the isomerization process using immobilized Sweetzyme enzyme, IT® were used in this study. Experiments were conducted at different reaction temperatures in the range of 50-70°C and glucose initial concentrations of 10, 15 and 20% and enzyme loading of 1g. Glucose concentrations dropped with time until equilibrium was reached. A first order kinetics for the steps was employed and Runge Kutta 4th order algorithm combined with a least square method were used to estimate the pre-experimental factor and activation energy for determination of the corresponding rate constants by solving the initial value problem of the suggested model using EZ-Solve software. Very good fits between experimental data and model prediction was obtained.

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“…To calculate them the external mass-transfer model developed previously, parameters for reaction and deactivation describing the process free of diffusional resistances as well as effective diffusion coefficient were applied and in details reported in earlier papers [23,28]. In the calculation presented in this work the lowest value of the effectiveness factor has been adopted corresponding to the initial biocatalyst activity as well as the kinetic parameters for reaction and deactivation in the process free of diffusional limitations [48,49].…”

Section: Evaluation Of the Effectiveness Factormentioning

confidence: 99%

Analytical Determination of the Optimal Feed Temperature for Hydrogen Peroxide Decomposition Process Occurring in Bioreactor with a Fixed-Bed of Commercial Catalase

Grubecki

2020

Catalysts

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The hydrogen peroxide-immobilized commercial catalase system was chosen to estimate the optimal feed temperature (OFT) for fixed-bed reactor (FXBR). This feed temperature was obtained based on analytical solution by maximizing the time-averaged substrate conversion under a constant feed flow rate and temperature constraints. In calculations a set of partial differential equations describing the conservation equation for fixed-bed reactor, assuming plug flow and kinetic equation for the rate of enzyme parallel deactivation was taken into account. The model is based on kinetic, and mass-transfer parameters estimated previously in a real decomposition process of hydrogen peroxide (HP). The simulation showed that the OFT is strongly dependent on hydrogen peroxide feed concentration, feed flow rate and diffusional resistances expressed by biocatalyst global effectiveness factor. It has been shown that the more significant diffusional resistances and the higher HP conversions are, the higher the optimal feed temperature is. The calculated values of the OFT were verified with the experimental results obtained in the model reactor at selected values of the feed flow rate. Presented analysis poses a significant simplification in a numerical computational procedure and can be very useful for engineers to select the temperature condition at which bioreactor productivity is expected to be maximal.

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Experimental and modeling study of catalytic reaction of glucose isomerization: Kinetics and packed‐bed dynamic modeling

Cited by 15 publications

References 25 publications

Industrial use of immobilized enzymes

Industrial use of immobilized enzymes

Kinetics of a Three-Step Isomerization of Glucose to Fructose Using Immobilized Enzyme

Analytical Determination of the Optimal Feed Temperature for Hydrogen Peroxide Decomposition Process Occurring in Bioreactor with a Fixed-Bed of Commercial Catalase

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