Experimental and modeling study of fluidized bed granulation: Effect of binder flow rate and fluidizing air velocity

Vengateson, U.; Mohan, Ratan

doi:10.1016/j.reffit.2016.10.003

Cited by 13 publications

(5 citation statements)

References 25 publications

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“…In addition, increasing the spray rate results in more availability of water in the spraying zone and, hence, more wetting and sticking of the particles [ 23 ]. This result is in agreement with previously reported work [ 23 , 24 ].…”

Section: Resultssupporting

confidence: 94%

Design Space Approach for the Optimization of Green Fluidized Bed Granulation Process in the Granulation of a Poorly Water-Soluble Fenofibrate Using Design of Experiment

et al. 2022

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In the pharmaceutical industry, the systematic optimization of process variables using a quality-by-design (QbD) approach is highly precise, economic and ensures product quality. The current research presents the implementation of a design-of-experiment (DoE) driven QbD approach for the optimization of key process variables of the green fluidized bed granulation (GFBG) process. A 32 full-factorial design was performed to explore the effect of water amount (X1; 1–6% w/w) and spray rate (X2; 2–8 g/min) as key process variables on critical quality attributes (CQAs) of granules and tablets. Regression analysis have demonstrated that changing the levels of X1 and X2 significantly affect (p ≤ 0.05) the CQAs of granules and tablets. Particularly, X1 was found to have the pronounced effect on the CQAs. The GFBG process was optimized, and a design space (DS) was built using numerical optimization. It was found that X1 and X2 at high (5.69% w/w) and low (2 g/min) levels, respectively, demonstrated the optimum operating conditions. By optimizing X1 and X2, GFBG could enhance the disintegration and dissolution of tablets containing a poorly water-soluble drug. The prediction error values of dependent responses were less than 5% that confirm validity, robustness and accuracy of the generated DS in optimization of GFBG.

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Section: Resultssupporting

confidence: 94%

Design Space Approach for the Optimization of Green Fluidized Bed Granulation Process in the Granulation of a Poorly Water-Soluble Fenofibrate Using Design of Experiment

et al. 2022

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“…La aglomeración por vía seca se realiza mediante etapas consecutivas de trituración, cribado y la compactación final del polvo; mientras que, la aglomeración húmeda, mayormente utilizada en la industria alimentaria, maneja una solución aglutinante pulverizada que actúa sobre un sistema de lecho fluidizado, donde las partículas humectadas chocan y se forman puentes líquido entre estas; al recibir suficiente calor del aire de fluidización, el líquido se evapora y las partículas quedan unidas, lo que genera la formación de un gránulo poroso y de mayor tamaño (Yuksel & Dirim, 2021;Machado et al, 2014;Ziyani & Fatah, 2014;Dhanalakshmi et al, 2011). La calidad del producto aglomerado depende de las condiciones de proceso: flujo de aire de fluidización, temperatura del aire de entrada, presión de pulverización y flujo de aglutinante) (Vengateson & Mohan, 2016). Procesos de aglomeración por lecho fluidizado en polvos de frutas y hortalizas han sido reportados por diversos autores: polvo de jugo de espinaca (Yuksel & Dirim, 2021), polvo de champiñón común , polvo de banano verde (Rayo et al, 2015); además, en otras matrices en polvo: aislado de proteína de soya (Machado et al, 2014), pectina (Hirata et al, 2013), leche en polvo descremada y entera (Barkouti et al, 2013), sémola de trigo duro (Saad et al, 2011), almidón de maíz (Ghosal et al, 2010), entre otros.…”

Section: Introductionunclassified

Production of mango powder by spray drying and cast-tape drying

et al. 2017

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“…On the other hand, a high flow rate resulted in a decrease in the RDI in treatments with 100 g pre-wet mass ( Table 4 ). Vengateson and Mohan [ 37 ] reported that increasing the binder flow rate caused the formation of bigger granules with more flowability and decreased bulk density and friability, which consequently improved the rehydration.…”

Section: Resultsmentioning

confidence: 99%

Characterization of a Commercial Whey Protein Hydrolysate and Its Use as a Binding Agent in the Whey Protein Isolate Agglomeration Process

Zaitoun

Palmer²,

Amamcharla

2022

Foods

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The first objective of this study was to characterize the chemical properties of three lots of whey protein hydrolysate (WPH) obtained from a commercial manufacturer. The degree of hydrolysis (DH) of WPH was between 13.82 and 15.35%, and was not significantly (p > 0.05) different between the batches. From MALDI-TOF, 10 to 13 different peptides were observed in the range of 2.5–5 kDa and 5–8 kDa, respectively. The second objective of the study was to evaluate the effectiveness of WPH as a binder in whey protein isolate (WPI) wet agglomeration. For this purpose, a 3 × 3 × 2 factorial design was conducted with pre-wet mass (60, 100, and 140 g), WPH concentration (15, 20, and 25%), and flow rate (4.0 and 5.6 mL·min−1) as independent variables. WPI agglomeration was carried out in a top-spray fluid bed granulator (Midi-Glatt, Binzen, Germany). Agglomerated WPI samples were stored at 25 °C and analyzed for moisture content (MC), water activity, relative dissolution index (RDI), and emulsifying capacity. Pre-wet mass, flow rate, and the WPH concentration had a significant (p < 0.05) effect on the MC. Moreover, all interactions among the main effects had also a significant (p < 0.05) effect on MC. High MC and water activity were observed for the treatments with a higher pre-wet volume and higher flow rate, which also resulted in clumping of the powders. The treatment with the 60 g pre-wet mass, 20% WPH concentration, and 5.6 mL·min−1 flow rate combination had the highest RDI among all the samples. In conclusion, WPH can be used as a potential alternative to soy lecithin in WPI wet agglomeration.

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Experimental and modeling study of fluidized bed granulation: Effect of binder flow rate and fluidizing air velocity

Cited by 13 publications

References 25 publications

Design Space Approach for the Optimization of Green Fluidized Bed Granulation Process in the Granulation of a Poorly Water-Soluble Fenofibrate Using Design of Experiment

Design Space Approach for the Optimization of Green Fluidized Bed Granulation Process in the Granulation of a Poorly Water-Soluble Fenofibrate Using Design of Experiment

Production of mango powder by spray drying and cast-tape drying

Characterization of a Commercial Whey Protein Hydrolysate and Its Use as a Binding Agent in the Whey Protein Isolate Agglomeration Process

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