Experimental and computational insight of the supramolecular complexes of Irbesartan with β-cyclodextrin based nanosponges

Suvarna, Vasanti; Singh, Vikas; Sharma, Dhvani; Murahari, Manikanta

doi:10.1016/j.jddst.2021.102494

Cited by 8 publications

(24 citation statements)

References 24 publications

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“…In this study, DSC was used to verify the physical state of the drug in the form tions (Figure 8). The DSC curve of pure irbesartan exhibited single endothermic peak 185.67 °C, which is designated as the melting point of the irbesartan [44,45]. All evalu formulations as well as the FH8 physical mixture showed broad endotherm correspo ing to the water evaporation and polymer relaxation [12,46].…”

Section: Dscmentioning

confidence: 99%

Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model

et al. 2021

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Selective laser sintering (SLS) is a rapid prototyping technique for the production of three-dimensional objects through selectively sintering powder-based layer materials. The aim of the study was to investigate the effect of energy density (ED) and formulation factors on the printability and characteristics of SLS irbesartan tablets. The correlation between formulation factors, ED, and printability was obtained using a decision tree model with an accuracy of 80%. FT-IR results revealed that there was no interaction between irbesartan and the applied excipients. DSC results indicated that irbesartan was present in an amorphous form in printed tablets. ED had a significant influence on tablets’ physical, mechanical, and morphological characteristics. Adding lactose monohydrate enabled faster drug release while reducing the possibility for printing with different laser speeds. However, formulations with crospovidone were printable with a wider range of laser speeds. The adjustment of formulation and process parameters enabled the production of SLS tablets with hydroxypropyl methylcellulose with complete release in less than 30 min. The results suggest that a decision tree could be a useful tool for predicting the printability of pharmaceutical formulations. Tailoring the characteristics of SLS irbesartan tablets by ED is possible; however, it needs to be governed by the composition of the whole formulation.

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Section: Dscmentioning

confidence: 99%

Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model

et al. 2021

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“…As a new family of spongy materials, CDNSs are solid, hyper-reticulated and nanoporous three-dimensional polymeric colloidal biodegradable nanostructures, typically having spherical shape ( Cecone et al, 2020 ; Rizzi et al, 2021 ; Sadjadi and Koohestani, 2021a ; Suvarna et al, 2021 ). In terms of structural regularity, CDNSs can be amorphous or crystalline frameworks ( Singh et al, 2017 ).…”

Section: Cyclodextrin-based Nanosponges: Synthesis and Propertiesmentioning

confidence: 99%

“…At the end of the reaction a fine homogeneous powder is obtained ( Jasim et al, 2020 ; Moin et al, 2020 ; Sadjadi and Koohestani, 2021a , 2021b ; Srivastava et al, 2021 ). The powdered substance is repeatedly washed with water and/or acetone, and, generally, it is also subjected to Soxhlet extraction with ethanol or acetone, and even to an additional washing with sodium hydroxide (NaOH) solution ( Kumar A. and Rao R., 2021 ; Sadjadi and Koohestani, 2021a , 2021b ; Suvarna et al, 2021 ). Water allows the removal of CD in excess and ethanol/acetone allows the elimination of the unreacted crosslinker and still other impurities such as phenol or imidazole, formed when DPC or CDI linkers are used, respectively.…”

Section: Cyclodextrin-based Nanosponges: Synthesis and Propertiesmentioning

confidence: 99%

“…In the case of using dianhydride linkers alone or with 2-hydroxyethyl disulphide ( Daga et al, 2016 ), the addition of triethylamine (Et 3 N) as basic catalyst is required, and the exothermic reaction occurs quickly at room temperature ( Nazerdeylami et al, 2021 ; Suvarna et al, 2021 ; Yazdani et al, 2021 ). Using other linkers, such as HDI ( Yazdani et al, 2021 ), MDI ( Khajeh Dangolani et al, 2019 ), DMC and DPC ( Singh et al, 2018 ), Et 3 N can also be introduced to increase the rate of the reaction, with or without an increase in temperature.…”

Section: Cyclodextrin-based Nanosponges: Synthesis and Propertiesmentioning

confidence: 99%

“…CDNSs are colloidal systems with an average diameter size generally below 1 µm and with a narrow size distribution, denoted by a polydispersity index (PDI) less than 0.7, which is typical of monodispersed particles ( Kumar et al, 2021 ). Their high ζ-potential (±30 mV), mostly showing a negatively charged surface, means that the particles easily disperse in water to form stable suspensions, whereby they tend to repel electrostatically, not acting as surfactants, as they do not aggregate ( Trotta et al, 2012 ; Suvarna et al, 2021 ). However, NSs can swell upon water absorption appearing to have a gel structure, as hydrogels.…”

Section: Cyclodextrin-based Nanosponges: Synthesis and Propertiesmentioning

confidence: 99%

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Cyclodextrin-Based Nanosponges: Overview and Opportunities

et al. 2022

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Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges. Cyclodextrins are cyclic oligomers of glucose derived from starch. The combined external hydrophilicity with the internal hydrophobic surface constitute a unique “microenvironment”, that confers cyclodextrins the peculiar ability to form inclusion host‒guest complexes with many hydrophobic substances. These complexes may impart beneficial modifications of the properties of guest molecules such as solubility enhancement and stabilization of labile guests. These properties complemented with the possibility of using different crosslinkers and high polymeric surface, make these sponges highly suitable for a large range of applications. Despite that, in the last 2 decades, cyclodextrin-based nanosponges have been developed for pharmaceutical and biomedical applications, taking advantage of the nontoxicity of cyclodextrins towards humans. This paper provides a critical and timely compilation of the contributions involving cyclodextrins nanosponges for those areas, but also paves the way for other important applications, including water and soil remediation and catalysis.

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Potential of cyclodextrin in hybrid liposomes for improving the solubility, bioavailability and stability of silibinin

Takke

Shende

2022

Chem. Pap.

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Experimental and computational insight of the supramolecular complexes of Irbesartan with β-cyclodextrin based nanosponges

Cited by 8 publications

References 24 publications

Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model

Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model

Cyclodextrin-Based Nanosponges: Overview and Opportunities

Potential of cyclodextrin in hybrid liposomes for improving the solubility, bioavailability and stability of silibinin

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