Experimental and clinical studies on the catecholamine metabolism

Kishikawa, Hidemi

doi:10.4044/joma1947.87.5-6_463

Cited by 6 publications

(3 citation statements)

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“…This is interesting when considering the differences and similarities between the present case and some epileptics. However, against to the hypothesis advanced by Kishikawa (1975) in which the HVA is reduced, the HVA in this patient was elevated. Kobayashi et al (1975) reported the increase of dopamine in serum and CSF of patients with movement-induced seizures, while Nakane (1974) also found aggravating effect of 1-DOPA in other patients with the same condition.…”

Section: Discussioncontrasting

confidence: 96%

“…Therefore, although natural relief could be expected in this condition even if left untreated, it is desirable to carry out therapy actively at an early stage. (Kishikawa 1975) this condition, to our knowledge. According to our study, there were no particular abnormalities in sleep rhythms and characters of REM stage, thus suggesting the absence of manifest disturbances of brain function in our case.…”

Section: Discussionmentioning

confidence: 70%

“…On the other hand, the fact that octopamine, which is not detectable in normal subjects (Kishikawa 1975), indicated high values suggests the existence of aberrant dopa-mine (DA) metabolism paths. Kishikawa (1975) detected octopamine in CSF of some epileptics and hypothesized the development of such shunt pathways as indicated in Fig. 6.…”

Section: Discussionmentioning

confidence: 85%

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Overnight Sleep EEG and Cerebrospinal Fluid Monoamines in Seizures Induced by Movement

Fukuyama¹,

Ochiai²,

Hayakawa³

et al. 1979

Neuropediatrics

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Clinical, electrical and biochemical studies in an eight years old boy with movement-induced seizures were reported. The attack was usually triggered by sudden initiation of movement, but rarely occurred without any apparent movement. Repeated jumping provoked attacks constantly, which was recorded cinematographically. No abnormality was found either in ictal or interictal EEGs. Haloperidol aggravated the condition, but 1-DOPA had no effect, while DPH (100 mg/day) controlled attacks perfectly with the serum DPH concentration of just 2.0 ug/dl. In overnight sleep analysis, sleep rhythms and characters of REM sleep were not differed significantly from the standard. After DPH therapy, stabilization of sleep in general was noticed; that is, total sleep time prolonged, number of sleep stages decreased and interrupting awakening disappeared. Probenecid loading test revealed that 5-HIAA was normal, HVA high, and large amount of octopamine was detected in CSF.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 70%

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Overnight Sleep EEG and Cerebrospinal Fluid Monoamines in Seizures Induced by Movement

Fukuyama¹,

Ochiai²,

Hayakawa³

et al. 1979

Neuropediatrics

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Catecholamine level in cerebrospinal fluid of epileptics

1982

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We estimated catecholamine levels in CSF of 15 epileptics and 75 non-neurological patients utilizing a high performance liquid chromatograph with a highly sensitive fluorometer and found the following results: The dopamine (DA) levels in males were significantly higher than those in females, while norepinephrine (NE) levels in males were the same as in females. The DA levels were significantly lower and NE levels significantly higher in epileptics than in non-neurological patients. DA and NE in petit mal patients were on the average lower than in grand mal patients, but untreated grand mal patients had higher NE levels. These results suggest that epilepsy may be associated with a disturbance of DA and/or NE metabolism or release in the brain.

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Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice

Suzuki

Mori

1992

Neurochem Res

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Tyrosine, tryptophan, and their metabolites in the brain of ddY, non-stimulated El (El (-)), and stimulated El (El (+)) mice were measured using the three dimensional HPLC. The tryptophan content was lower in El (+) than ddY and El (-) mice. The 5-hydroxytryptophan content was much higher in both El groups. The serotonin content of El (+) was higher than that of ddY and El (-) mice. The kynurenine content was remarkably high in the El mice. The dopamine content was lower in El (-) than in ddY mice, whereas it was greater in El (+) than in El (-) mice. The norepinephrine showed higher levels in El (+) mice. These facts suggest that El mice possess congenital metabolic abnormalities of tryptophan and tyrosine and that kynurenine may play an important role as convulsant in El mice seizures along with changes in serotonin, dopamine, and norepinephrine that are inhibitory agents and responded to the repetitive convulsions.

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Experimental and clinical studies on the catecholamine metabolism

Cited by 6 publications

References 0 publications

Overnight Sleep EEG and Cerebrospinal Fluid Monoamines in Seizures Induced by Movement

Overnight Sleep EEG and Cerebrospinal Fluid Monoamines in Seizures Induced by Movement

Catecholamine level in cerebrospinal fluid of epileptics

Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice

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