Experimental and Clinical Observations with Guanethidine

Guanethidine and Chlorthalidonein Hypertension

“…Initial higher doses, e.g., 25 mg, may cause troublesome side effects from the very beginning and thus bring the method of treatment in miscredit by the patient. Sasamoto et al (32) when using guanethidine alone, also pointed out the im portance of gradually increasing doses.…”