Experimental and Clinical Left or Biventricular Assist Device with Local Heparinization and Blood Filtration

Taguchi, Kazumi; Mochizuki, Tetsuya; Murashita, J; Maruyaman, T.; Takata, Ichiro; Iwamiya, H; Tagami, S

doi:10.1007/978-3-642-67268-2_26

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“…However, nonpulsatile bypass flow of 30-40% of the cardiac output has been effective for prolonged maintenance of cardiac function in normal calves and has produced recovery of patients with successful weaning. Unlike our technique, auxiliary ventricles [7,8] are more complicated since they require accurate timing and volume control and sometimes result in unexpected cardiac dysfunction with elevated ventricular enddiastolic pressure. We consider the left or biventricular bypass with local heparinizaiton and blood filtration to be the procedure of choice in support of a failing cardiac output.…”

Section: Discussionmentioning

confidence: 99%

Transapical left ventricular bypass with local heparinization for prolonged circulatory support

et al. 1980

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An avcothanized vinyl sheet consisting of a Pall filter, 2 pressure monitoring lilnes, 2 heparinization lines, and a roller pump was used for transapical left ventricular bypass in 36 calves and 11 patients. Blood was returned to the abdominal or ascending aorta or carotid artery. Prolonged left ventricular flow unloading was carried out. All 31 calves that underwent left ventricular bypass and 5 calves that underwent left ventricular bypass and 5 calves that underwent biventricular bypass survived the scheduled period of bypass of up to 7 weeks except for 2 calves that died of accidental air embolism and 2 that were deliberately sacrificed due to infection. Local heparinization for 6 days followed by oral anticoagulation to maintain the prothrombin time at 150-200% of normal were effective in keeping the animals from bleeding and preventing thromboembolism. Eleven critically ill patients with severe heart disease were supported with left or biventricular bypass for periods of up to 172 hours. Four patients ultimately recovered, and 3 others were successfully weaned from bypass and expired 1-4 months later.

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Section: Discussionmentioning

confidence: 99%