Experimental and clinical antihypertensive activity of Matricaria chamomilla extracts and their angiotensin‐converting enzyme inhibitory activity

Abstract

Three different extracts of Matricaria chamomilla L. were evaluated for their antihypertensive activity, these extracts were total alcohol extract (Extract 1), oil extracted (Extract 2), and water lifted after oil extraction (Extract 3). Quantitative and Qualitative analyses were carried out for all extracts. The 3 extracts were proved to be safe for human use. A single oral administration of the plant extracts (200 mg/kg) decreases both systolic and diastolic blood pressure of normotensive rats after 1, 1.5, and 2 hr. Furthermore, groups treated with the evaluated extracts (100 & 200 mg/kg) or Captopril (20 mg/kg) showed a significant reduction in the elevated blood pressure and heart rate. Extract 3 showed the most antihypertensive activity. Serum biochemical parameters and lipid profile levels of treated groups were improved in comparison with induced-hypertensive untreated rats. In evaluation of oxidative damage parameters Glutathione and superoxide dismutase (SOD) in some organs, the investigated extracts or captopril restored the amount of reduced Glutathione in tissues in addition to an increase in the activity of the SOD after a significant depletion of SOD activity. In the clinical study, there was a significant dose dependent decrease in Systolic blood pressure, Diastolic blood pressure, and heart rate compared with their basal values in both normotensive and hypertensive human volunteers after oral administration of Matricaria chamomilla beverages.

microRNAs E SUAS APLICAÇÕES COMO POSSÍVEIS ALVOS TERAPÊUTICOS PARA TERAPIA GÊNICA

“…Os artigos apresentados nos resultados tratavam-se de ensaios clínicos realizados em diferentes regiões do mundo. Os estudos compartilham em seus desfechos a redução das pressões sanguíneas sistêmicas dos pacientes com hipertensão, crise hipertensiva e insuficiência cardíaca após a administração do captopril (ARNOLD et al, 2013;AWAAD et al, 2018;AZEVEDO et al, 2017;SALKIC et al, 2015;SUSALIT et al, 2011;YILMAZ et al, 2011), assim como a Pressão Arterial Diastólica (PAD) (AZEVEDO et al, 2017;SALKIC et al, 2015;SUSALIT et al, 2011). A PAS diminuiu de maneira semelhante, ficando entre os intervalos 11 e 13,7 mm Hg (ARNOLD et al, 2013;SUSALIT et al, 2011).…”

“…Estados Unidos(ARNOLD et al, 2013), Bósnia e Herzegovina(SALKIC et al, 2015),Canadá (AZEVEDO et al, 2017) e Arábia Saudita(AWAAD et al, 2018). Quatro (66,7%) dos estudos da amostra final eram ensaios clínicos, sendo dois (33,3%) deles randomizados.…”

“…Conforme reportado nos resultados(ARNOLD et al, 2013;AWAAD et al, 2018; AZEVEDO et al, 2017;SALKIC et al, 2015;SUSALIT et al, 2011;YILMAZ et al, 2011), assim como a Pressão Arterial Diastólica (PAD)(AZEVEDO et al, 2017;SALKIC et al, 2015;SUSALIT et al, 2011), o captopril possui uma significante função hipotensora no tratamento de pacientes acometidos por DCV.…”

In vitro antibacterial activity of an aqueous extracts of Matricaria chmomilla flowers against pathogenic bacteria isolated from pregnant women with urinary tract infection

“…In this study, we aimed to evaluate the antibacterial effect of three concentrations (50, 100 and 150) mg/ml of cold-water and boiling-water extracts of M. chmomilla flowers to inhibit growth of pathogenic bacteria isolated from urine of pregnant women with UTI, the results showed that 150mg Table 3, and there was non-significant differences (P-value>0.05) in antibacterial effect between imipenem 10 µg (positive control) and 150 mg/ml of hot-water extracts (Table 4). Matricaria chamomilla is an important medicinal plant was used in treatment of many infections such as respiratory tract infections and gastrointestinal tract infections in many countries [34]. Matricaria chamomilla flowers was used as antipyretic and carminative, in addition, flowers oil has been used in colic, flatulence and rheumatism [35].…”

The Potential Cardioprotective Effect of Matricaria Chamomilla Extract Against Diabetes-Induced Oxidative Stress in Rats

“…The decrease in BP, following the administration of the extract, may be due to the amelioration of lipid homeostasis and/or the ability of the extract to relieve hyperglycaemia in diabetic animals. In a previous study, the effect of M. chamomilla L. on blood pressure was evaluated in rats [24]. The total alcohol extract from the aerial parts of the plant showed blood pressure lowering effects in hypertensive rats, with ACE inhibitory activity as a mechanism of action.…”