Experimental analysis of the role of ECM in the patterning of the distal tendons of the developing limb bud

Hurlé, Juan M.; Ros, María A.; Gañán, Yolanda; Macias, D.; Critchlow, Matthew A.; Hinchliffe, J. R.

doi:10.1016/0922-3371(90)90078-b

Cited by 56 publications

(63 citation statements)

References 21 publications

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“…As the incipient digit mesenchyme of the early bud, the tip of growing digits is a complex region undergoing cell aggregation . However upon cell aggregation, the distal mesoderm of the autopod is also able to develop into the precursors of the digit tendons that are formed in close relation with cartilaginous aggregates (Hurle et al, 1990, Schweitzer et al, 2001. At molecular level TGFβs/Activins and BMP signaling are confluent at these places.…”

Section: Discussionmentioning

confidence: 99%

Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits

Lorda‐Diez

Torre-Pérez²,

García‐Porrero³

et al. 2009

Int. J. Dev. Biol.

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Section: Discussionmentioning

confidence: 99%

Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits

Lorda‐Diez

Torre-Pérez²,

García‐Porrero³

et al. 2009

Int. J. Dev. Biol.

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“…In situ hybridization was carried out as described previously [6]. Thc following procedures were performed at room temperature unless noted otherwise.…”

Section: Situ Iii~hritlizcrtion ~Tlioke Tmurtt In Situ Izjhridizutiunmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Muscle cells originate from their precursor cells in the somites while other connective tissues and skeletal elements are from the lateral plate mesoderm [2,[5][6][7][8]10,19,20]. The fates of muscle and skeletal primordia are not completely determined until certain stage of development [5,6,10,20]. For example, when skeletal cartilage precursor cells were grafted into a particular region destined to become soft tissues such as tendons in stage 20 chick embryo, the grafted cells change their fate and differentiate into tendon tissue, suggesting that these cartilage precursor cells are plastic in terms of their capability to differentiate into other type of connective tissue cells [20].…”

Section: Introductionmentioning

confidence: 99%

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Coordinated expression of scleraxis and Sox9 genes during embryonic development of tendons and cartilage

Asou

Nifuji

Tsuji

et al. 2002

Journal Orthopaedic Research

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Embryonic development of tendons is in close association with that of cartilage and bone. Although these tissues are derived from mesenchymal progenitor cells which also give rise to muscle and fat, their fates clearly diverse in early embryonic stages. Transcription factors may play pivotal roles in the process of determination and differentiation of tendon cells as well as other cells in the skeletal system. Scleruxis, a basic helix-loop-helix (bHLH) type transcription factor, is expressed in mesenchymal progenitors that later form connective tissues including tendons. Sox9 is an HMG-box containing transcription factor, which is expressed at high levels in chondrocytes. We hypothesized that the two transcription factors regulate the fate of cells that interact with each other at the interface between the two tissues during divergence of their differentiation pathways. To address this point, we investigated .scleraxis and Sox9 mRNA expression during mouse embyogenesis focusing on the coordinated development of tendons and skeletons. In the early stage of mesenchymal tissue development at 10.5 d.p.c., sclcruxis and Sox9 transcripts were expressed in thc mesenchymal progenitor cells in the appendicular and axial mesenchyme. At 11.5 d.p.c., sclrraxis transcripts were observed in the mesenchymal tissue surrounding skeletal primordia which express SoxY. From this stage, scleruxis expression was closely associated with, but distinct from, formation of skeletal primordia. At 13.5 d.p.c., scleruxis was expressed broadly in the interface between muscle and skeletal primordia while Sox9 expression is confined within the early skeletal primordia. Then, at 15.5 d.p.c., .sc,lm/si.s transcripts were more restricted to tendons. These observations revealed the presence of temporal and spatial association of sc1wtr.vi.s expression during embryonic development of tendon precursor cells in close association with that of Sox9 expression in chondrogenic cells in skeletal tissues.

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“…This differential behaviour of distal tendons vs. intermediate and proximal tendons, in the absence of muscles can be explained by the fact that distal limb tendons form independently and then gradually join to intermediate tendons to generate the complete pattern of tendon (Kardon, 1998). In addition, there is not much muscle at the digit level and autopod tendon formation is more associated with cartilage development (Hurle et al, 1990;D'Souza and Patel, 1999;Schweitzer et al, 2001). Inhibition of digit cartilage formation by means of apical ectodermal ridge (AER) removal leads abnormal tendons, while ectopic digits generated by interdigital ectoderm removal resulted in induction of ectopic tendons, indicating that the presence of a cartilage element is sufficient for induction of a digit tendon (Hurle et al, 1990).…”

Section: Phase 2: Separation Of Scleraxis Expression From Muscle Massesmentioning

confidence: 99%

Signals regulating tendon formation during chick embryonic development

Edom-Vovard

Duprez

2004

Developmental Dynamics

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Frédé rique Edom-Vovard and Delphine Duprez * Tendons are collagen-rich structures that link muscle to cartilage. By using quail-chick chimeras, it has been shown that tendon and cartilage cells originate from the same mesodermic compartment, which is distinct from that giving rise to muscle cells. Axial tendons originate from the sclerotomal compartment, and limb tendons originate from the lateral plate, whereas axial and limb muscles derive from dermomyotomes. Despite these different embryologic origins, muscle and tendon morphogenesis occurs in close spatial and temporal association. Facilitated by the distinct embryologic origin of myogenic and tendon cells, surgical studies in the avian embryo have highlighted interactions between tendons and muscles, during embryonic development. However, these interactions seem to differ between axial and limb levels. The molecular mechanisms underlying muscle and tendon interactions have been shown recently to involve different members of the fibroblast growth factor family. This review covers the available data on the early steps of tendon formation in the limb and along the primary axis. The relationship with muscle morphogenesis will be highlighted. Developmental Dynamics 229:449 -457, 2004.

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Experimental analysis of the role of ECM in the patterning of the distal tendons of the developing limb bud

Cited by 56 publications

References 21 publications

Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits

Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits

Coordinated expression of scleraxis and Sox9 genes during embryonic development of tendons and cartilage

Signals regulating tendon formation during chick embryonic development

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