Experimental analysis of the mechanical behavior of the viscoelastic porcine pancreas and preliminary case study on the human pancreas

Wex, Cora; Fröhlich, M.; Brandstädter, K.; Bruns, Christiane; Stoll, Anke

doi:10.1016/j.jmbbm.2014.10.013

Cited by 29 publications

(17 citation statements)

References 27 publications

(33 reference statements)

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“…Tensile and compression testing have also been employed to characterise soft biological samples [ 100 , 101 ]. The viscoelastic properties of human and porcine pancreata have also been tested using rheometer and plate systems [ 102 , 103 ]. Human and porcine pancreatic tissue were seen to behave similarly in terms of their viscoelastic properties.…”

Section: Ex Vivo Assessment Of Pdac Biomechanicsmentioning

confidence: 99%

“…Human and porcine pancreatic tissue were seen to behave similarly in terms of their viscoelastic properties. However, these were not PDAC samples [ 102 ], although this does indicate the possible validity of equating porcine pancreas biomechanics to that of humans. Viscoelastic properties were also observed to change with time post resection [ 103 ], reflecting a potential logistics issue for the ex vivo study of cancer tissue mechanics.…”

Section: Ex Vivo Assessment Of Pdac Biomechanicsmentioning

confidence: 99%

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Pancreatic Ductal Adenocarcinoma: Relating Biomechanics and Prognosis

MacCurtain

Quirke

Thorpe

et al. 2021

JCM

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Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and carries a dismal prognosis. Resectable patients are treated predominantly with surgery while borderline resectable patients may receive neoadjuvant treatment (NAT) to downstage their disease prior to possible resection. PDAC tissue is stiffer than healthy pancreas, and tissue stiffness is associated with cancer progression. Another feature of PDAC is increased tissue heterogeneity. We postulate that tumour stiffness and heterogeneity may be used alongside currently employed diagnostics to better predict prognosis and response to treatment. In this review we summarise the biomechanical changes observed in PDAC, explore the factors behind these changes and describe the clinical consequences. We identify methods available for assessing PDAC biomechanics ex vivo and in vivo, outlining the relative merits of each. Finally, we discuss the potential use of radiological imaging for prognostic use.

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Section: Ex Vivo Assessment Of Pdac Biomechanicsmentioning

confidence: 99%

Section: Ex Vivo Assessment Of Pdac Biomechanicsmentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma: Relating Biomechanics and Prognosis

MacCurtain

Quirke

Thorpe

et al. 2021

JCM

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show abstract

“…In fact, the pancreas is a non-linear viscoelastic soft tissue. The shear stiffness of healthy pancreatic tissue was found to be in the range of 1–2 kPa (Wex et al, 2015), whereas the stiffness of polyesters is higher, namely elastic modulus is generally in the range of 6–7 GPa for polyglycolide (Van de Velde and Kiekens, 2002) and 2–3 GPa in the case of polylactic acid and poly(lactic-co-glycolic) acid (Gentile et al, 2014). On the other hand, porous scaffolds used in the previously mentioned studies did not resemble pancreas morphology and a justification for the architecture selection is not generally reported.…”

Section: Pancreas In Vitro Modelsmentioning

confidence: 99%

Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models

Caddeo

Boffito

Sartori

2017

Front. Bioeng. Biotechnol.

211

172

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In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined to develop bioartificial substitutes for organs and tissues, which can in turn be applied in regenerative medicine, pharmaceutical, diagnostic, and basic research to elucidate fundamental aspects of cell functions in vivo or to identify mechanisms involved in aging processes and disease onset and progression. The complex three-dimensional (3D) microenvironment in which cells are organized in vivo allows the interaction between different cell types and between cells and the extracellular matrix, the composition of which varies as a function of the tissue, the degree of maturation, and health conditions. In this context, 3D in vitro models can more realistically reproduce a tissue or organ than two-dimensional (2D) models. Moreover, they can overcome the limitations of animal models and reduce the need for in vivo tests, according to the “3Rs” guiding principles for a more ethical research. The design of 3D engineered tissue models is currently in its development stage, showing high potential in overcoming the limitations of already available models. However, many issues are still opened, concerning the identification of the optimal scaffold-forming materials, cell source and biofabrication technology, and the best cell culture conditions (biochemical and physical cues) to finely replicate the native tissue and the surrounding environment. In the near future, 3D tissue-engineered models are expected to become useful tools in the preliminary testing and screening of drugs and therapies and in the investigation of the molecular mechanisms underpinning disease onset and progression. In this review, the application of TE principles to the design of in vitro 3D models will be surveyed, with a focus on the strengths and weaknesses of this emerging approach. In addition, a brief overview on the development of in vitro models of healthy and pathological bone, heart, pancreas, and liver will be presented.

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“…Fractional order models for metal polymer composite was discussed in [7]. In [8,9] viscoelastic properties for a large variety of biological entities were studied. A class of sensors based on fractional calculus was presented in [10].…”

Section: Introductionmentioning

confidence: 99%

Exoskeleton Hand Control by Fractional Order Models

Ivănescu

Popescu

et al. 2019

Sensors

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This paper deals with the fractional order control for the complex systems, hand exoskeleton and sensors, that monitor and control the human behavior. The control laws based on physical significance variables, for fractional order models, with delays or without delays, are proposed and discussed. Lyapunov techniques and the methods that derive from Yakubovici-Kalman-Popov lemma are used and the frequency criterions that ensure asymptotic stability of the closed loop system are inferred. An observer control is proposed for the complex models, exoskeleton and sensors. The asymptotic stability of the system, exoskeleton hand-observer, is studied for sector control laws. Numerical simulations for an intelligent haptic robot-glove are presented. Several examples regarding these models, with delays or without delays, by using sector control laws or an observer control, are analyzed. The experimental platform is presented.

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Experimental analysis of the mechanical behavior of the viscoelastic porcine pancreas and preliminary case study on the human pancreas

Cited by 29 publications

References 27 publications

Pancreatic Ductal Adenocarcinoma: Relating Biomechanics and Prognosis

Pancreatic Ductal Adenocarcinoma: Relating Biomechanics and Prognosis

Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models

Exoskeleton Hand Control by Fractional Order Models

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