Experimental allergic chorioretinitis in rabbits by immunization to homologous retina in adjuvant

Schröder, K. D.; Meyer, Wolfgang; Hempel, E; Tilgner, S.

doi:10.1007/bf00414949

Cited by 7 publications

(1 citation statement)

References 28 publications

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“…Various patterns of EAU have been observed in studies employing similar but incompletely characterized antigen mixtures. Following the isolation and identification of a soluble retinal antigen ('s' antigen) [15] as an important etiologic agent, it has been reported that animals which appeared to have clinically and histopathologically different diseases actually represented extremes of the dose-associated response range to retinal 's' antigen [11], Considerable variation in histopathology exists among reports of EAU in rabbits [1,7,13,14,18], ranging from primarily an anterior uveitis in one study [1], to a chorioretinitis without anterior segment disease in others [13,14]. The antigens used in all of these experiments were unpurified retinal extracts so that the potential variations in effective immunopathogenic dose and the potential confounding effects of more than one immunopathogen make these studies difficult to compare.…”

Section: Introductionmentioning

confidence: 99%

Immunopathologic Responses of Rabbits to Retinal ‘s’ Antigen

Wacker¹,

Rao²,

Marak³

1981

Ophthalmic Res

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Experimental allergic uveitis induced in rabbits with purified ‘s’ antigen has dose-dependent features similar to the disease in guinea pigs. Unlike guinea pigs and other species the uveitis induced by ‘s’ antigen in rabbits demonstrates minimal anterior segment inflammation possibly because the rabbit is unique among mammals in having no anterior ciliary vessels, and few anastamoses between anterior segment and choroidal circulation.

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Section: Introductionmentioning

confidence: 99%

Immunopathologic Responses of Rabbits to Retinal ‘s’ Antigen

Wacker¹,

Rao²,

Marak³

1981

Ophthalmic Res

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Hyperacute form of experimental autoimmune uveo-retinitis in lewis rats; electron microscopic study

Kozak

Thillaye

Renard

et al. 1978

Albrecht von Graefes Arch. Klin. Ophthalmol.

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One systemic injection of retinal tissue or extract mixed with Freund's complete adjuvant induces uveo-retinitis in several animal species: guinea pig [6], rabbit [5, 7], monkey [4] and rat [8]. Rod outer segments may be used as the pathogenic antigenic preparation [1, 3, 9]. This study reports on the conditions of induction of experimental autoimmune uveo-retinitis (EAU) in rats (susceptible strains of rats, optimal doses of antigen and adjuvant) and the histopathological features of the lesions in the early stages of the disease. In several species one systemic injection of retinal tissue or extract mixed with Freund's complete adjuvant induces an ocular inflammatory disease, whose main features are an inflammatory infiltration of the uvea and a destruction of the external layers of the retina. With adequate doses of guinea pig retinal extract and adjuvant, the disease was induced in all cases in albino rats of the Lewis strain. The vascular and tissular lesions, and the infiltrates with a predominance of PMN's and basophils seem to be the result of immune complexe deposition.

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