Experiências de Formação em Artes na Amazônia

Carneiro, Leonel Martins; Araujo, Hanna Talita Gonçalves Pereira de

doi:10.35170/ss.ed.9786586283372

Cited by 1 publication

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“…Sialic acids are negatively charged sugars expressed at the terminal positions of N-and O-linked oligosaccharides, which are attached to cell surfaces or secreted glycoproteins. As a result of their non-reducing terminal position, sialic acids are involved in highly specific recognition phenomena [133,134] [ [116][117][118][119][120][121][122] predominantly express α-2-6-specific sialyltransferases and α-2-6-linked sialic acid residues in glycoprotein N-glycans [135]. Interestingly, inflammation stimuli induced a shift from α-2-6-linked towards α-2-3-linked sialic acid, suggesting that α-2-6-linked sialic acid can be used as a biomarker for quality control in amplified human cartilage.…”

Section: Autologous Cartilage/chondrocyte Implantationmentioning

confidence: 99%

Glycosphingolipids in Osteoarthritis and Cartilage Regeneration Therapy: Mechanisms and Therapeutic Prospects

Homan,

Onodera,

Matsuoka

et al. 2024

Preprint

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Glycosphingolipids (GSLs), a subtype of glycolipids containing sphingosine, are critical components of vertebrate plasma membranes, playing a pivotal role in cellular signaling and interactions. In human articular cartilage in osteoarthritis (OA), GSL expression is known notably to decrease. This review focuses on the roles of gangliosides, a specific type of GSL, in cartilage degeneration and regeneration, emphasizing their regulatory function in signal transduction. The expression of gangliosides, whether endogenous or augmented exogenously, is regulated at the enzymatic level, targeting specific glycosyltransferases. This regulation has significant implications for the composition of cell surface gangliosides and their impact on signal transduction in chondrocytes and progenitor cells. Different levels of ganglioside expression can influence signaling pathways in various ways, potentially affecting cell properties, including malignancy. Moreover, gene manipulations against gangliosides have been shown to regulate cartilage metabolism and chondrocyte differentiation in vivo and in vitro. This review highlights the potential of targeting gangliosides in the development of therapeutic strategies for osteoarthritis and cartilage injury and addresses promising directions for future research and treatment.

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