Experiences With the Use of Radioactive Colloidal Gold in the Treatment of Cancer*

Historical Perspective on Nanoparticles in Imaging from 1895 to 2000

“…The gamma emission that penetrated freely through the body became important for imaging. Produced colloidal gold nanoparticles were small enough (3-7 nm) [8] to pass through the pulmonary capillaries (<7 µm) but were accumulating mostly in the liver and spleen [9]. at higher dosages, even bone marrow could be visualized.…”

Role of Cytotoxic Agents in Production of Amyloidosis in Hodgkin's Disease

“…A further 88 patients reported by Weisberger (1958) showed approximately the same percentage-64-to be improved, and again the most favourable response was obtained in patients with breast and ovarian tumours. In a series of 25 patients with bronchial carcinoma described by Bass (1960) five with malignant effusions were treated by the direct intrapleural injection of HN2, there being no reaccumulation of fluid up to the time of death in four.Many authors agree (King et al, 1952;Storaasli et al, 1953 ;Kent et al, 1954;Wheeler et al, 1955) that Au-198 can produce slowing down or cessation of malignant effusions in about 50-60% of patients, and that the best response is obtained where the primary tumour arises in the breast or ovary. Hilton et al (1957) reported the results of treatment with Au-198 of 94 patients at University College Hospital.…”

Nitrogen Mustard in Palliation of Malignant Effusions

“…Many authors agree (King et al, 1952;Storaasli et al, 1953 ;Kent et al, 1954;Wheeler et al, 1955) that Au-198 can produce slowing down or cessation of malignant effusions in about 50-60% of patients, and that the best response is obtained where the primary tumour arises in the breast or ovary. Hilton et al (1957) reported the results of treatment with patients at University College Hospital.…”