Experiences with Acetylcysteine in Cystinuric Patients

Mulvaney, William P.; Quilter, Thomas N.; Mortera, Antonio

doi:10.1016/s0022-5347(17)66955-6

Cited by 40 publications

(9 citation statements)

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“…The list of 113 genes whose electronic signal was less than twofold higher than background levels can be inferred, by exclusion, from the Atlas™ Mouse Stress Array gene list (available on the website http://atlas/info.clontech.com) no detrimental effects (34). In humans, doses of0.5 g/kg body wt per os (35) or 0.3 g/kg body wt intravenously ( 36) were given when NAC was used as an antidote to acute intoxications. Other details regarding NAC safety in clinical trials are reported in Subheading 3.3.…”

Section: Pharmacokinetics and Safety Of Nacmentioning

confidence: 99%

Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine

Flora¹,

Izzotti²,

Albini³

et al. 2004

Cancer Chemoprevention

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Section: Pharmacokinetics and Safety Of Nacmentioning

confidence: 99%

Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine

Flora¹,

Izzotti²,

Albini³

et al. 2004

Cancer Chemoprevention

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“…Acetylcysteine has previously been used for treatment, prevention and dissolution of cystine renal stones [13,14]. The drug was recognized as a liquefying expectorant due to its mucolytic properties.…”

Section: Discussionmentioning

confidence: 99%

Uric Acid Urolithiasis and Crystallization Inhibitors

et al. 1999

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An in vitro study of the inhibitory effects that some substances occasionally present in urine can provoke on the crystallization of uric acid has been performed. The most remarkable crystallization inhibitory effects were produced by mucine at concentrations of >0.5 mg/l. Pentosan polysulfate and chondroitin sulfate also clearly increased the uric acid crystallization times at concentrations of >100 mg/l. Saponins, such as escin and glycyrrhizic acid, also produced a notable delay in uric acid crystallization times at concentrations of >10 mg/l. Similar effects were observed in the presence of a surfactant substance, lauryl sulfate. N-Acetyl-L-cysteine caused crystallization perturbations only when it was present at concentrations of >50 mg/l. Citric acid and phytic acid caused no effects on uric acid crystallization even at the highest concentrations assayed (1,000 and 5 mg/l, respectively). From the results obtained it can be deduced that mainly glycoproteins, glycosaminoglycans and surfactant substances can exert protective effects against uric acid crystallization.

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“…Intervals to complete stone dissolution have ranged from 9 to 42 days (Smith et al, 1979;Dretler et al, 1984). Acetylcysteine is thought to act by opening disulfide bonds and thus reducing the dimer cystine to the more soluble monomer cysteine (Mulvaney et al, 1975). The time required for complete dissolution of cystine stones can be reduced by using a combination of chemolysis and ESWL.…”

Section: Commentmentioning

confidence: 99%