“…Also, all realizations of w(t), v k and x 0 are assumed to be taken from mutually independent Gaussian distributions. Thus, the continuousdiscrete stochastic state-space model (1), (2) is best suited for state estimation in chemical systems and widely used in chemistry research and industrial applications (see, for instance, Wilson et al (1998); Soroush (1998); Dochain (2003); Rawlings (2002, 2005); Jørgensen (2007); Rawlings and Bakshi (2006); Romanenko and Castro (2004); ). Concerning state estimation algorithms, we have to remark that, at present, there exist a great variety of different methods starting from a rigorous probabilistic approach solving Kolmogorov's (Fokker-Planck's) forward equation (as discussed, for instance, in Jazwinski (1970); Maybeck (1982)) till approximate approaches including various nonlinear modifications and implementations of the well-known Kalman filter (see Lewis (1986); Singer (2002Singer ( , 2006; Julier et al (2000); Julier and Uhlmann (2004); Ito and Xiong (2000); Nørgaard et al (2000); Haykin (2008, 2009); Arasaratnam et al (2010); Frogerais et al (2012); Jørgensen et al (2007); Kulikov and Kulikova (2014); Rawlings and Bakshi (2006); Romanenko and Castro (2004); ; Schneider and Georgakis (2013)) as well as optimization based approaches usually referred to as the moving horizon estimation (studied by Jang et al (1986); Rao et al (2001); Rawlings (2002, 2005); Rawlings and Bakshi (2006) and so on).…”