Experiences from treatment of out-of-hospital cardiac arrest during 17 years in Göteborg

Herlitz, Johan

doi:10.1053/euhj.2000.2150

Cited by 150 publications

(86 citation statements)

References 17 publications

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“…An amiodarone vs. lidocaine trial reported VF prevalence among pre-hospital cardiac arrests, of only 26% (33). Similar reports were published from Goteborg, Sweden documenting a decrease in VF prevalence of 39% over 17 years despite significant improvements in response time and rates of bystander cardiopulmonary resuscitation (34). Prevalence of PEA among sudden cardiac arrest cases rose from 6% to 26% during 1980-96 (34).…”

Section: Presenting Arrhythmia In Patients Who Suffer Sudden Cardiac supporting

confidence: 57%

“…Similar reports were published from Goteborg, Sweden documenting a decrease in VF prevalence of 39% over 17 years despite significant improvements in response time and rates of bystander cardiopulmonary resuscitation (34). Prevalence of PEA among sudden cardiac arrest cases rose from 6% to 26% during 1980-96 (34). What are the causes of this altered prevalence and why is it important?…”

Section: Presenting Arrhythmia In Patients Who Suffer Sudden Cardiac supporting

confidence: 55%

See 1 more Smart Citation

Epidemiology of Sudden Cardiac Death: Clinical and Research Implications

Chugh

Reinier

Teodorescu

et al. 2008

Progress in Cardiovascular Diseases

597

458

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The current annual incidence of sudden cardiac death in the US is likely to be in the range of 180-250,000 per year. Coinciding with the decreased mortality from coronary artery disease, there is evidence pointing toward a significant decrease in rates of sudden cardiac death in the US during the second half of the twentieth century. However the alarming rise in prevalence of obesity and diabetes in the first decade of the new millennium both in the US and worldwide, would indicate that this favorable trend is unlikely to persist. We are likely to witness a resurgence of coronary artery disease and heart failure, as a result of which sudden cardiac death will have to be confronted as a shared and indiscriminate, worldwide public health problem. There is also increasing recognition of the fact that discovery of meaningful and relevant risk stratification and prevention methodologies will require careful prospective community-wide analyses, with access to large archives of DNA, serum and tissue that link with well-phenotyped databases. The purpose of this review is to summarize current knowledge of sudden cardiac death epidemiology. We will discuss the significance and strengths of community-wide evaluations of sudden cardiac death, summarize recent observations from such studies, and finally highlight specific potential predictors that warrant further evaluation as determinants of sudden cardiac death in the general population.

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Section: Presenting Arrhythmia In Patients Who Suffer Sudden Cardiac supporting

confidence: 57%

Section: Presenting Arrhythmia In Patients Who Suffer Sudden Cardiac supporting

confidence: 55%

Epidemiology of Sudden Cardiac Death: Clinical and Research Implications

Chugh

Reinier

Teodorescu

et al. 2008

Progress in Cardiovascular Diseases

597

458

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“…Even when return of spontaneous circulation (ROSC) is achieved, more than half of the survivors suffer serious neurologic dysfunction. [1][2][3] New therapeutic strategies are needed to improve patient survival and outcomes. Hydrogen sulfide (H 2 S) has been shown to have a variety of protective actions in various models of tissue and organ injury.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide Inhalation Decreases Early Blood—Brain Barrier Permeability and Brain Edema Induced by Cardiac Arrest and Resuscitation

Geng

et al. 2015

J Cereb Blood Flow Metab

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The effects of hydrogen sulfide (H 2 S) on blood-brain barrier (BBB) and brain edema after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) remain poorly understood. We investigated the effects of exogenous 80-p.p.m. H 2 S gas on BBB, brain water content, neurologic outcome, and survival rate after CA and CPR. Cardiopulmonary resuscitation followed CA induced in rats by ventricular fibrillation for 6 minutes. Results show that inhalation of 80-p.p.m. H 2 S significantly reduced the permeability of the BBB in both in the cortex and hippocampus at 24 hours after resuscitation. Hydrogen sulfide also lessened brain edema in the cortex and hippocampus, ameliorated neurologic outcome as evaluated by neurologic deficit score and tape removal test, and improved the 14-day survival rate. Hydrogen sulfide also attenuated CA and CPR-induced increases of matrix metalloproteinase-9 (MMP-9) activity and vascular endothelial growth factor (VEGF) expression, and increased the expression of angiogenin-1 (Ang-1). These results indicate that inhalation of 80-p.p.m. H 2 S immediately after CPR attenuated BBB permeability and brain edema, and improved neurologic outcome and 14-day survival of rats after CA. The therapeutic benefits of H 2 S could be associated with suppression of MMP-9 and VEGF expression and increased expression of Ang-1.

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“…In a significant proportion of patients, SCD can present without warning or a recognized triggering mechanism. The mean age of those affected is in the mid 60s, and at least 40% of patients will suffer SCD before the age of 65 [14].There is also strong evidence from studies in North America and Europe that there are significantly altered trends in the presenting arrhythmia observed by first responders among SCD cases [23,24]. The prevalence of SCD cases presenting with VF is decreasing with a corresponding increase in the proportion of cases presenting with pulseless electric activity (PEA).…”

Section: Sudden Cardiac Deathmentioning

confidence: 95%