Experience with Real-Time Continuous Glucose Monitoring in Newborns with Congenital Hyperinsulinemic Hypoglycemia

Abstract

Background Effective treatment and close monitoring of hypoglycemia in children with congenital hyperinsulinemic hypoglycemia (CHH) is vital to prevent brain damage. The current use of capillary sampling schedules does not provide a comprehensive assessment of glycemic status and fails to detect asymptomatic hypoglycemia episodes. Aim To investigate the efficacy and accuracy of a real-time continuous glucose monitoring system (RT-CGMS) in neonates with CHH. Methods A sensor connected to RT-CGMS was inserted into the newborn patients and maintained for at least 6 days during their stay in the hospital. We compared the readings of CGMS with capillary blood glucose values using Bland-Altman analysis. Results A total of 110 blood glucose values were compared to readings from the CGMS. All results were calculated and plotted for CGMS values at 0–4, 5–9, 10–14, 15–19, 20–24, and 25–29 min after capillary blood glucose sampling. CGMS readings were highly correlated with blood glucose values, especially during normoglycemia. In case of hypoglycemia, the mean difference between the CGMS and capillary glucose values was higher. Although the false positive rate for hypoglycemia was relatively high in CGMS, RT-CGMS may show some episodes of hypoglycemia earlier than blood measurement. Conclusion RT-CGMS is accurate during normoglycemia, and it can reduce the number of capillary blood samples in children with CHH.

Clinical, Genetic Features and Treatment Results in Patients with Congenital Hyperinsulinemic Hypoglycemia: A Single Center Experience

“…Uzun dönemde hastaların yaklaşık yarısında bilişsel fonksiyonlarda bozulma bildirilmiştir(1). Ancak son 20 yılda KHH'nin tanı ve tedavisindeki gelişme ve ilerlemeler ile subkutan devamlı kan şekeri monitörizasyonu gibi yakından izlem yöntemleri, hastaların nörolojik sonuçlarında kayda değer iyileşme sağlamıştır(38,48). Nörolojik etkilenme üzerinde hastaların tanı yaşı, ek hastalık varlığı, ilk hipoglisemi atağının şiddeti ve hipoglisemi ataklarının sıklığı gibi faktörler rol oynamaktadır(38).…”