Experience with Polygynax used in the treatment of vulvovaginitis caused by the aerobic and mixed microflora

Радзинский, В. Е.; Ордиянц, И. М.; Побединская, О. С.; Radzinsky, V.E.; Ordiyants, I.M.; Pobedinskaya, O. S.; Zykov, E. V.

doi:10.17116/rosakush201616184-88

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…Крім того, змінюється співвідношення строгих анаеробів і аеробів, за якого виділяються переважно представники сімейств Enterobacteriaceae і Micrococcaceae. До групи мікроорганізмів, що не входять до складу нормобіоценозу, низка дослідників відносять також Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae, Listeria monocytogenes [19,20]. Дисбіотичні порушення, які є Г І Н Е К О Л О Г І Я головною ланкою патогенезу вагінальних інфекцій, рекомендують коригувати при погіршенні якості життя жінки і появі суб'єктивно неприємної симптоматики (виділень з піхви, свербежу, дискомфорту у ділянці статевих органів), порушень сечовипускання, больового синдрому під час сексуальних контактів [21,22 ].…”

Section: комбинированные препараты в локальной терапии инфекционных вульвовагинитовприоритетное направление сегодняшнего дня ви мамчур снunclassified

“…Однак при цьому дисбіозі вагінального біотопа нижні відділи статевого тракту масивно колонізуються умовно-патогенними мікроорганізмами, які є основними збудниками гнійно-запальних захворювань органів малого таза. Такі бактерії, як Staphylocоccus spp., Streptocоccus spp., коліформні бактерії (Escherichia coli), розглядаються сучасними дослідниками як найбільш часті збудники хоріоамніоніту, інтраамніальної інфекції, післяпологового ендометриту, післяопераційних запальних ускладнень [20,31,33,34].…”

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Combined drugs in local therapy of infectious vulvovaginitis are a priority area of today

Мамчур

Дронов

2021

RHW

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One of the key and strategically important problems of modern gynecology both around the world and in Ukraine is infectious and inflammatory diseases (IVD) of the lower genital tract: according to various estimates, back in the 90s of the last century, this diagnosis was made in about 40 % of patients in gynecological hospitals. Over the first decade of the 21st century, the incidence rate of genital IVI increased 1.4 times in 18–24-year-old patients, and 1.8 times in 25–29-year-old patients. At the same time, the costs of diagnostics and treatment have increased, which reach 50-60% of all costs for the provision of gynecological care to the population.In the structure of gynecological morbidity, the indicator of the number of patients with infectious and inflammatory diseases of the genital area continues to occupy a leading position in terms of frequency in the population, amounting to 60.4-65.0%, however, information from different authors regarding their true prevalence is very contradictory. So, according to the materials of the 33rd European Congress of the International Union against for Sexually Transmitted Infections (IUSTI-Europe), bacterial vaginosis (BV) occurs in 12-80% of women, vulvovaginal candidiasis – VVC (at least one episode in life) - in 75%, aerobic vaginitis (AV) – in 15-25% [8]. According to other authors, the prevalence of BV is 24-30%, VVC – 9.7-11.7%, nonspecific (aerobic) vaginitis – 5.0-23.7%.Combined drugs Neo-Penotran® Forte and Gainomax have a high safety profile, which is due to the unique features of the pharmacokinetics and pharmacodynamics of their components. This determines the advantages in the speed of bactericidal action over other antibacterial and antimycotic agents. These drugs are highly effective in the local treatment of BV and vulvovaginal infections, reaching 98.5% in some nosologies.The effectiveness and safety of the use of Neo-Penotran® Forte and Gainomax in the treatment of infections of the female genital area served as the basis for their inclusion in standard treatment regimens according to indications, and their use is regulated by the normative documents of the Ministry of Health of Ukraine.

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Combined drugs in local therapy of infectious vulvovaginitis are a priority area of today

Мамчур

Дронов

2021

RHW

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Mixed vaginitis. What's new? Features of the course and therapy of mixed vaginitis

Dobrokhotova¹,

Markova²

2022

Probl. reprod.

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Problematic issues of diagnosis and treatment of vulvovaginitis of mixed bacterial-candidiasis etiology

Беленичев

2021

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The aim of the study is to evaluate the effectiveness of modern antiseptic agent Gynodek in the treatment of mixed bacterial-candidiasis vulvovaginitis.Materials and methods. There were 67 patients with bacterial-candidiasis vulvovaginitis under observation. The diagnosis of candidiasis infection was verified according to the data of clinical and laboratory research methods. Patients received vaginal gel Gynodek 5 ml once a day for 7 days. The effectiveness of treatment was assessed according to the data of the clinical examination before treatment and on the 7th day of observation, and according to the laboratory (bacterioscopic, bacteriological) data before and after treatment. Complete clinical and bacterial debridement was criteria of the treatment effectiveness.Results and discussion. The clinical picture of bacterial-fungal vulvovaginitis was characterized by a decrease in the number and severity of symptoms such as hyperemia and edema of the mucous membrane, discharge from the genital tract was not typical.There were no complaints in 95.5% of the examined women after end of therapy, there were no objective symptoms in all women on the 7th day of treatment. Bacteriological examination after 2 weeks confirmed the therapy effectiveness in 86.6% of women. Peptostreptococcus spp. after treatment sowed at significant concentrations 106–107 CFU/ml only in 1.5% of patients, Streptococcus spp. in 8.9% of women, Candida albicans in 13.4%. Lactobacilli in the amount of 107 CFU/ml were in 86.6% of patients, which indicates a rapid restoration of normal vaginal microflora.Conclusions. Bacterial-fungal associations of microorganisms in the vaginal biotope lead to a complex clinical symptoms, which makes it difficult to make a timely diagnosis. Gynodek vaginal gel is highly effective against gram-positive, gram-negative and fungal microflora, which makes it the drug of choice in the treatment of bacterial-candidiasis vulvovaginitis. Gynodek creates a comfortable pH, promotes the rapid restoration of own lactoflora, and increases the functional activity of the vaginal mucosa epithelium, which ensures the prevention of vaginal infection recurrence.

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Experience with Polygynax used in the treatment of vulvovaginitis caused by the aerobic and mixed microflora

Cited by 4 publications

References 3 publications

Combined drugs in local therapy of infectious vulvovaginitis are a priority area of today

Combined drugs in local therapy of infectious vulvovaginitis are a priority area of today

Mixed vaginitis. What's new? Features of the course and therapy of mixed vaginitis

Problematic issues of diagnosis and treatment of vulvovaginitis of mixed bacterial-candidiasis etiology

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Experience with Polygynax used in the treatment of vulvovaginitis caused by the aerobic and mixed microflora

Cited by 4 publications

References 3 publications

Combined drugs in local therapy of infectious vulvovaginitis are a priority area of ​​today

Combined drugs in local therapy of infectious vulvovaginitis are a priority area of ​​today

Mixed vaginitis. What's new? Features of the course and therapy of mixed vaginitis

Problematic issues of diagnosis and treatment of vulvovaginitis of mixed bacterial-candidiasis etiology

Contact Info

Product

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Combined drugs in local therapy of infectious vulvovaginitis are a priority area of today

Combined drugs in local therapy of infectious vulvovaginitis are a priority area of today