Experience with phenylephrine as a component of the pharmacologie support of septic shock

Cardiovascular management of septic shock

“…Phenylephrine, as a pure ␣ agonist, might be expected to decrease cardiac output (CO) as it raises blood pressure. However, at least one study documented an increase in CO with phenylephrine (68). Although only one small single-center, prospective, randomized study has shown benefit of norepinephrine over dopamine, recent literature reports some potential advantages of norepinephrine (74).…”

Treatment of severe lactic acidosis during the pre-anhepatic stage of liver transplant surgery with intraoperative hemodialysis

“…At doses of 10 μg/kg/min, dopamine significantly improved hepatic oxygenation [24] and increased portal and total HBF during hypoxia, while having no effect on HBF at any dose [25]. Phenylephrine, which was also used throughout the case to compensate for the low SVR and to maintain MAP around 75 to 80 mmHg, has no effect on lactate production and hepatic lactate utilization [23], and it has been associated with a substantial decrease in blood lactate concentrations [26]. At least one animal study supports the lack of effect of dopamine and phenylephrine on lactic acidosis during liver transplant surgery [27].…”

Traitement de la défaillance circulatoire

“…Cette étude, qui a évalué les paramètres de transport de l'oxygène, n'a pas mis en évidence de modifi cation signifi cative de la consommation ou de l'apport en oxygène. La phényléphrine a été administrée à 13 patients en choc septique présentant une hypotension persistante malgré une optimisation de la volémie et l'administration de petites doses de dopamine ou de dobutamine [41]. L'index cardiaque de base était de 3,3 l/min/m 2 et la pression artérielle moyenne de 57 mm de mercure.…”