Experience With Needle Biopsy for Coccidioidal Lung Nodules

Forseth, James; Rohwedder, Jay J.; Levine, Bernard E.; Saubolle, Michael A.

doi:10.1001/archinte.1986.00360140141020

Cited by 40 publications

(23 citation statements)

References 3 publications

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“…As many as 30% of lung nodules biopsied in the area of endemicity are due to coccidioidomycosis (161). Histologic examination is more sensitive than culture for detection of coccidioidal lung nodules (162,163). Patients with asymptomatic lung nodules do not benefit from antifungal therapy (160).…”

Section: Complicated Pulmonary Coccidioidomycosismentioning

confidence: 99%

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

et al. 2013

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SUMMARY Coccidioidomycosis is the endemic mycosis caused by the fungal pathogens Coccidioides immitis and C. posadasii . This review is a summary of the recent advances that have been made in the understanding of this pathogen, including its mycology, genetics, and niche in the environment. Updates on the epidemiology of the organism emphasize that it is a continuing, significant problem in areas of endemicity. For a variety of reasons, the number of reported coccidioidal infections has increased dramatically over the past decade. While continual improvements in the fields of organ transplantation and management of autoimmune disorders and patients with HIV have led to dilemmas with concurrent infection with coccidioidomycosis, they have also led to advances in the understanding of the human immune response to infection. There have been some advances in therapeutics with the increased use of newer azoles. Lastly, there is an overview of the ongoing search for a preventative vaccine.

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Section: Complicated Pulmonary Coccidioidomycosismentioning

confidence: 99%

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

et al. 2013

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“…The diagnosis of a solitary pulmonary nodule as being due to coccidioidomycosis is often made upon thoractomy (52,53). If the patient's history and the serological and skin tests suggest a differential diagnosis of coccidioidomycosis, a transthoracic needle biopsy specimen showing spherules may obviate the need for surgery (54).…”

Section: Diagnosis Of Coccidioides Immitis Infectionmentioning

confidence: 99%

Coccidioidomycosis

Bronnimann

Galgiani

1989

Eur. J. Clin. Microbiol. Infect. Dis.

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Coccidioidomycosis is a largely self-limited fungal respiratory illness. However, the infrequent case of progressive or disseminated disease can be devastating. As international travel to and from endemic areas increases, physicians unfamiliar with the disease may be called upon to recognize and treat serious coccidioidal infections. The major risk factors for dissemination are race and immunosuppression. The most common sites of dissemination are the skin, lymph nodes, bone and meninges. Diagnosis is aided by investigation of the patient's clinical history, delayed-type hypersensitivity skin test reaction, serologic testing, and recovery of organisms from infected tissue or secretions for direct examination and culture. Fungicidal agents are not available, fortunately, fungistatic therapy allows many patients to recover. The availability of both intravenous/intrathecal and oral agents now allows more therapeutic flexibility in the treatment of this disease.

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“…Additionally, continued improvements in radiographic imaging may someday allow for the avoidance of invasive diagnostic procedures. Utilizing current CT scans, the fraction of concerning lung nodules that require invasive studies to differentiate from lung cancer remains at 33 %, the same fraction as reported in 1986 using chest X-ray imaging [48]. Newer modalities such as PET-CT have been incompletely studied in the evaluation of coccidioidomycosis and results thus far have been unsatisfactory with frequent false-positives and false-negatives alike.…”

Section: What Host Genetic Factors Predispose Certain Individuals Andmentioning

confidence: 96%

Call for a California Coccidioidomycosis Consortium to Face the Top Ten Challenges Posed by a Recalcitrant Regional Disease

et al. 2014

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Experience With Needle Biopsy for Coccidioidal Lung Nodules

Cited by 40 publications

References 3 publications

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

Coccidioidomycosis

Call for a California Coccidioidomycosis Consortium to Face the Top Ten Challenges Posed by a Recalcitrant Regional Disease

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