“…Estrogens have usually been considered the culprit. Most authors think that progesterone, on the other hand, does not raise BP (2,4,11,13,14,17,18) and so may be used as a contraceptive agent without fear of causing hypertension. Leiman (9), however, reported significant BP changes in 24% of 1050 patients treated with medroxyprogesterone acetate (MPA) (Depo-Provera, The Upjohn Company, Kalamazoo, MI, USA) as defined by increases or decreases in systolic (20 mm Hg) and/or diastolic (10 mm Hg) BP.…”