Experience with gestational surrogacy as a treatment for sterility resulting from hysterectomy

Abstract

A retrospective study was carried out to assess the potential of 16 hysterectomized women to achieve surrogate pregnancies. A total of 11 patients completed 16 cycles of assisted conception treatment incorporating in-vitro fertilization and gestational surrogacy. Three other women failed to respond to ovulation induction while two more patients produced few oocytes which also failed to fertilize. Six host mothers became pregnant thereby giving a pregnancy rate of 37.5% (6/16) per patient and embryo transfer and 27.3% (6/22) per cycle of treatment commenced. Two women later miscarried, three have given birth to twins and the remaining host has delivered a male infant. The commissioning mother's age was closely related to occurrence and continuation of pregnancy in the host. Hysterectomized women demonstrate varying patterns of response to assisted conception treatment but gestational surrogacy generally appears to be a feasible option especially in younger patients.

Experience of in vitro fertilization surrogacy in Finland

“…In both groups there were only a few poor responders. Meniru and Craft (1997) demonstrated varying patterns of ovarian response in women who had undergone hysterectomy (7). Goldfarb et al.…”

“…Thus far, there are only a few reports describing pregnancy results associated with IVF surrogacy and most treatments have been carried out in the United States (3, 6–10). Meniru and Craft (1997) reported six IVF surrogate pregnancies among 16 genetic mothers in whom hysterectomy had been carried out (7). Corson et al.…”

Faisabilité de la congélation embryonnaire dans la préservation de la fertilité féminine

“…Cas particulier de la pré servation de la fertilité en cas d'hysté rectomie La pré servation de la fertilité fé minine dans les cancers gyné cologiques, lorsqu'une hysté rectomie est indiqué e, est proposé e par de nombreuses é quipes, en particulier dans les pays où la grossesse pour autrui est autorisé e [41,42]. Cette attitude est cependant discutable et discuté e dans un pays comme la France [43].…”

Uterine transplantation: a promising surrogate to surrogacy?

“…Gestational surrogacy has been used as an assisted reproductive treatment alternative whereby a woman gestates genetically unrelated embryos produced in an in vitro fertilization (IVF) laboratory with the gametes of a commissioning couple 7 . The first pregnancy following gestational surrogacy was reported 25 years ago; 8 since then, gestational surrogacy has become a viable remedy for couples who would otherwise be unable to conceive because of a nonfunctional uterus, excessive medical risk associated with pregnancy, or from failed attempts at conception with standard treatment options 9–14 . However, due to its complicated ethical issues, gestational surrogacy is outlawed in many countries worldwide.…”

“…7 The first pregnancy following gestational surrogacy was reported 25 years ago; 8 since then, gestational surrogacy has become a viable remedy for couples who would otherwise be unable to conceive because of a nonfunctional uterus, excessive medical risk associated with pregnancy, or from failed attempts at conception with standard treatment options. [9][10][11][12][13][14] However, due to its complicated ethical issues, gestational surrogacy is outlawed in many countries worldwide. In order to avoid the ethical considerations raised by IVF surrogacy, such as the autonomy doi: 10.1111/j.1749-6632.2011.05952.x of the surrogate mother, possible risks for both embryo and surrogate carrier, and the psychological implication for the child, 15,16 the development of a successful uterine transplantation technique would offer women displaying severe uterine infertility an option to become social, genetic, and gestational mothers.…”