Experience with Fresh Venous Allografts as an Arterial Substitute

Ochsner, John L.; DeCamp, Paul T.; Leonard, George L.

doi:10.1097/00000658-197106010-00011

Cited by 79 publications

(8 citation statements)

References 3 publications

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“…Several studies have shown that there may be a component of "rejection" that occurs with the use of CSV that is mediated by both humoral and cellular responses. [8][9][10] We found ABO mismatch to be associated with early bypass graft occlusion, and the use of a donor vein with B or AB blood type was associated with both early and late graft occlusion. Several other studies have suggested that these factors may contribute to adverse limb-related events in the setting of CSV for lower extremity revascularization.…”

Section: Discussionmentioning

confidence: 77%

Cryopreserved saphenous vein as a last-ditch conduit for limb salvage

O’Banion

Eichler

et al. 2017

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 77%

Cryopreserved saphenous vein as a last-ditch conduit for limb salvage

O’Banion

Eichler

et al. 2017

Journal of Vascular Surgery

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“…Several decades ago, pioneering studies by Ochsner et al 130 attempted the reconstruction of occluded small arteries in the leg by using fresh leg vein allografts. They reported more frequent early failure of ABO-incompatible allografts.…”

Section: Abo Incompatibility and Heart Valve And Vein Transplantsmentioning

confidence: 99%

The histo‐blood group ABO system and tissue transplantation

Eastlund¹

1998

Transfusion

126

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In general, one might expect that ABO incompatibility of donor and recipient would be important to some degree if viability of the transplanted allograft is important for graft incorporation and function. This is true for some recipients of organs. However, ABO incompatibility appears to play a minor role, if any, in the clinical success of viable cornea and viable skin allografts. Even though A and B antigens may be present on the transplanted tissue, other factors that can contribute include the strength of the immune response, the avidity of the antibody, and the dose of the antigen presented, which may vary from donor to donor. Although A and B antigens are present on endothelium, the use of ABO-incompatible heart valves is successful, as they carry out their mechanical function by using the strength of the connective tissue rather than the viability of the donor endothelium. The presence, immunogenicity, and significance of A and B antigens in human vessel transplants have not been well studied. With the more commonly transplanted tissue, such as bone and tendon, posttransplant success does not depend on cellular viability or ABO compatibility.

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“…25, 26 We harvest these veins, usually from vein stripping procedures, and repair all leaks, preserving them by freezing at zero to four degrees centigrade in a solution of heparin-Ringer's solution with antibiotic. These veins are discarded if not used within three to four months.…”

Section: Femoral and Popliteal Artery Inflow Areamentioning

confidence: 99%